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Microfluidic devices powered by integrated elasto-magnetic pumps

We show how an asymmetric elasto-magnetic system provides a novel integrated pumping solution for lab-on-a-chip and point of care devices. This monolithic pumping solution, inspired by Purcell's 3-link swimmer, is integrated within a simple microfluidic device, bypassing the requirement of exte...

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Autores principales: Binsley, Jacob L., Martin, Elizabeth L., Myers, Thomas O., Pagliara, Stefano, Ogrin, Feodor Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654506/
https://www.ncbi.nlm.nih.gov/pubmed/33094306
http://dx.doi.org/10.1039/d0lc00935k
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author Binsley, Jacob L.
Martin, Elizabeth L.
Myers, Thomas O.
Pagliara, Stefano
Ogrin, Feodor Y.
author_facet Binsley, Jacob L.
Martin, Elizabeth L.
Myers, Thomas O.
Pagliara, Stefano
Ogrin, Feodor Y.
author_sort Binsley, Jacob L.
collection PubMed
description We show how an asymmetric elasto-magnetic system provides a novel integrated pumping solution for lab-on-a-chip and point of care devices. This monolithic pumping solution, inspired by Purcell's 3-link swimmer, is integrated within a simple microfluidic device, bypassing the requirement of external connections. We experimentally prove that this system can provide tuneable fluid flow with a flow rate of up to 600 μL h(–1). This fluid flow is achieved by actuating the pump using a weak, uniform, uniaxial, oscillating magnetic field, with field amplitudes in the range of 3–6 mT. Crucially, the fluid flow can be reversed by adjusting the driving frequency. We experimentally prove that this device can successfully operate on fluids with a range of viscosities, where pumping at higher viscosity correlates with a decreasing optimal driving frequency. The fluid flow produced by this device is understood here by examining the non-reciprocal motion of the elasto-magnetic component. This device has the capability to replace external pumping systems with a simple, integrated, lab-on-a-chip component.
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spelling pubmed-76545062020-11-17 Microfluidic devices powered by integrated elasto-magnetic pumps Binsley, Jacob L. Martin, Elizabeth L. Myers, Thomas O. Pagliara, Stefano Ogrin, Feodor Y. Lab Chip Chemistry We show how an asymmetric elasto-magnetic system provides a novel integrated pumping solution for lab-on-a-chip and point of care devices. This monolithic pumping solution, inspired by Purcell's 3-link swimmer, is integrated within a simple microfluidic device, bypassing the requirement of external connections. We experimentally prove that this system can provide tuneable fluid flow with a flow rate of up to 600 μL h(–1). This fluid flow is achieved by actuating the pump using a weak, uniform, uniaxial, oscillating magnetic field, with field amplitudes in the range of 3–6 mT. Crucially, the fluid flow can be reversed by adjusting the driving frequency. We experimentally prove that this device can successfully operate on fluids with a range of viscosities, where pumping at higher viscosity correlates with a decreasing optimal driving frequency. The fluid flow produced by this device is understood here by examining the non-reciprocal motion of the elasto-magnetic component. This device has the capability to replace external pumping systems with a simple, integrated, lab-on-a-chip component. Royal Society of Chemistry 2020-11-21 2020-10-23 /pmc/articles/PMC7654506/ /pubmed/33094306 http://dx.doi.org/10.1039/d0lc00935k Text en This journal is © The Royal Society of Chemistry 2020 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Binsley, Jacob L.
Martin, Elizabeth L.
Myers, Thomas O.
Pagliara, Stefano
Ogrin, Feodor Y.
Microfluidic devices powered by integrated elasto-magnetic pumps
title Microfluidic devices powered by integrated elasto-magnetic pumps
title_full Microfluidic devices powered by integrated elasto-magnetic pumps
title_fullStr Microfluidic devices powered by integrated elasto-magnetic pumps
title_full_unstemmed Microfluidic devices powered by integrated elasto-magnetic pumps
title_short Microfluidic devices powered by integrated elasto-magnetic pumps
title_sort microfluidic devices powered by integrated elasto-magnetic pumps
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654506/
https://www.ncbi.nlm.nih.gov/pubmed/33094306
http://dx.doi.org/10.1039/d0lc00935k
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