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Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature

Polymeric nanomaterials have become a prominent area of research in the field of drug delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of various therapeutics or contrast agents. There are many studies for developing new pol...

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Autores principales: Karabasz, Alicja, Bzowska, Monika, Szczepanowicz, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654520/
https://www.ncbi.nlm.nih.gov/pubmed/33192061
http://dx.doi.org/10.2147/IJN.S231477
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author Karabasz, Alicja
Bzowska, Monika
Szczepanowicz, Krzysztof
author_facet Karabasz, Alicja
Bzowska, Monika
Szczepanowicz, Krzysztof
author_sort Karabasz, Alicja
collection PubMed
description Polymeric nanomaterials have become a prominent area of research in the field of drug delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of various therapeutics or contrast agents. There are many studies for developing new polymeric nanocarriers; however, their clinical application is somewhat limited. In this review, we present new complex and multifunctional polymeric nanocarriers as promising and innovative diagnostic or therapeutic systems. Their multifunctionality, resulting from the unique chemical and biological properties of the polymers used, ensures better delivery, and a controlled, sequential release of many different therapeutics to the diseased tissue. We present a brief introduction of the classical formulation techniques and describe examples of multifunctional nanocarriers, whose biological assessment has been carried out at least in vitro. Most of them, however, also underwent evaluation in vivo on animal models. Selected polymeric nanocarriers were grouped depending on their medical application: anti-cancer drug nanocarriers, nanomaterials delivering compounds for cancer immunotherapy or regenerative medicine, components of vaccines nanomaterials used for topical application, and lifestyle diseases, ie, diabetes.
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spelling pubmed-76545202020-11-12 Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature Karabasz, Alicja Bzowska, Monika Szczepanowicz, Krzysztof Int J Nanomedicine Review Polymeric nanomaterials have become a prominent area of research in the field of drug delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of various therapeutics or contrast agents. There are many studies for developing new polymeric nanocarriers; however, their clinical application is somewhat limited. In this review, we present new complex and multifunctional polymeric nanocarriers as promising and innovative diagnostic or therapeutic systems. Their multifunctionality, resulting from the unique chemical and biological properties of the polymers used, ensures better delivery, and a controlled, sequential release of many different therapeutics to the diseased tissue. We present a brief introduction of the classical formulation techniques and describe examples of multifunctional nanocarriers, whose biological assessment has been carried out at least in vitro. Most of them, however, also underwent evaluation in vivo on animal models. Selected polymeric nanocarriers were grouped depending on their medical application: anti-cancer drug nanocarriers, nanomaterials delivering compounds for cancer immunotherapy or regenerative medicine, components of vaccines nanomaterials used for topical application, and lifestyle diseases, ie, diabetes. Dove 2020-11-06 /pmc/articles/PMC7654520/ /pubmed/33192061 http://dx.doi.org/10.2147/IJN.S231477 Text en © 2020 Karabasz et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Karabasz, Alicja
Bzowska, Monika
Szczepanowicz, Krzysztof
Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_full Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_fullStr Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_full_unstemmed Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_short Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature
title_sort biomedical applications of multifunctional polymeric nanocarriers: a review of current literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654520/
https://www.ncbi.nlm.nih.gov/pubmed/33192061
http://dx.doi.org/10.2147/IJN.S231477
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