MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

BACKGROUND: In follicular lymphoma (FL), histologic transformation to high-grade FL and diffuse large B-cell lymphoma (DLBCL) is a critical adverse step in disease progression. Activation of the oncogene c-MYC and tumor microenvironment remodeling account for FL progression. A panel of microRNA (miR...

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Detalles Bibliográficos
Autores principales: Lou, Xiaoli, Fu, Jianhong, Zhao, Xin, Zhuansun, Xuemei, Rong, Chao, Sun, Maomin, Niu, Hui, Wu, Lei, Zhang, Yongsheng, An, Lu, Guo, Lingchuan, Wan, Shan, Wang, Shouli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654609/
https://www.ncbi.nlm.nih.gov/pubmed/33168041
http://dx.doi.org/10.1186/s13046-020-01747-z

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