Cargando…

Efficacy and safety of dolutegravir plus emtricitabine versus standard ART for the maintenance of HIV-1 suppression: 48-week results of the factorial, randomized, non-inferiority SIMPL’HIV trial

BACKGROUND: Dolutegravir (DTG)–based dual therapy is becoming a new paradigm for both the initiation and maintenance of HIV treatment. The SIMPL’HIV study investigated the outcomes of virologically suppressed patients on standard combination antiretroviral therapy (cART) switching to DTG + emtricita...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sculier, Delphine, Wandeler, Gilles, Yerly, Sabine, Marinosci, Annalisa, Stoeckle, Marcel, Bernasconi, Enos, Braun, Dominique L., Vernazza, Pietro, Cavassini, Matthias, Buzzi, Marta, Metzner, Karin J., Decosterd, Laurent A., Günthard, Huldrych F., Schmid, Patrick, Limacher, Andreas, Egger, Matthias, Calmy, Alexandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654764/ https://www.ncbi.nlm.nih.gov/pubmed/33170863 http://dx.doi.org/10.1371/journal.pmed.1003421

Ejemplares similares

Adverse events of raltegravir and dolutegravir
por: Elzi, Luigia, et al.
Publicado: (2017)

Stable HIV‐1 reservoirs on dolutegravir maintenance monotherapy: the MONODO study
por: Sculier, D, et al.
Publicado: (2018)

Virologic failure and HIV drug resistance on simplified, dolutegravir-based maintenance therapy: Systematic review and meta-analysis
por: Wandeler, Gilles, et al.
Publicado: (2019)

Impact of the M184V/I Mutation on the Efficacy of Abacavir/Lamivudine/Dolutegravir Therapy in HIV Treatment-Experienced Patients
por: Olearo, Flaminia, et al.
Publicado: (2019)

Corrigendum to: Impact of the M184V/I Mutation on the Efficacy of Abacavir/Lamivudine/Dolutegravir Therapy in HIV Treatment-Experienced Patients
por: Olearo, Flaminia, et al.
Publicado: (2019)

Increases in Condomless Sex in the Swiss HIV Cohort Study
por: Kouyos, Roger D., et al.
Publicado: (2015)

Life expectancy in HIV-positive persons in Switzerland: matched comparison with general population
por: Gueler, Aysel, et al.
Publicado: (2017)

Inferring the age difference in HIV transmission pairs by applying phylogenetic methods on the HIV transmission network of the Swiss HIV Cohort Study
por: Kusejko, Katharina, et al.
Publicado: (2018)

Minor Protease Inhibitor Mutations at Baseline Do Not Increase the Risk for a Virological Failure in HIV-1 Subtype B Infected Patients
por: Scherrer, Alexandra U., et al.
Publicado: (2012)

Transient detectable viremia and the risk of viral rebound in patients from the Swiss HIV Cohort Study
por: Young, Jim, et al.
Publicado: (2015)

Female Genital Mutilation/Cutting in the Swiss HIV Cohort Study: A Cross-Sectional Study
por: Mauri, Fabio, et al.
Publicado: (2022)

Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis
por: Turk, Teja, et al.
Publicado: (2017)

Adherence as a Predictor of the Development of Class-Specific Resistance Mutations: The Swiss HIV Cohort Study
por: von Wyl, Viktor, et al.
Publicado: (2013)

Association of Incomplete Adherence to Antiretroviral Therapy With Cardiovascular Events and Mortality in Virologically Suppressed Persons With HIV: The Swiss HIV Cohort Study
por: Castillo-Mancilla, Jose R, et al.
Publicado: (2021)

HBV genotypes and response to tenofovir disoproxil fumarate in HIV/HBV-coinfected persons
por: Bihl, Florian, et al.
Publicado: (2015)

Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study
por: Sculier, Delphine, et al.
Publicado: (2017)

Correction: Long-Lasting Protection of Activity of Nucleoside Reverse Transcriptase Inhibitors and Protease Inhibitors (PIs) by Boosted PI Containing Regimens
por: Scherrer, Alexandra U., et al.
Publicado: (2013)

Long-Lasting Protection of Activity of Nucleoside Reverse Transcriptase Inhibitors and Protease Inhibitors (PIs) by Boosted PI Containing Regimens
por: Scherrer, Alexandra U., et al.
Publicado: (2012)

A Comparison of Initial Antiretroviral Therapy in the Swiss HIV Cohort Study and the Recommendations of the International AIDS Society-USA
por: Wandeler, Gilles, et al.
Publicado: (2011)

Comparison of five different risk scores to predict incident type 2 diabetes in the Swiss HIV cohort study
por: Blondet, Fanny, et al.
Publicado: (2023)

The Cumulative Impact of Harm Reduction on the Swiss HIV Epidemic: Cohort Study, Mathematical Model, and Phylogenetic Analysis
por: Marzel, Alex, et al.
Publicado: (2018)

Predictors of Virological Failure and Time to Viral Suppression of First-Line Integrase Inhibitor–Based Antiretroviral Treatment
por: Pyngottu, Ashima, et al.
Publicado: (2020)

The Individualized Genetic Barrier Predicts Treatment Response in a Large Cohort of HIV-1 Infected Patients
por: Beerenwinkel, Niko, et al.
Publicado: (2013)

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
por: Wan, Chenjie, et al.
Publicado: (2020)

IL-4 polymorphism influences susceptibility to Pneumocystis jirovecii pneumonia in HIV-positive patients
por: Wójtowicz, Agnieszka, et al.
Publicado: (2019)

Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland
por: Shilaih, Mohaned, et al.
Publicado: (2016)

Disentangling Human Tolerance and Resistance Against HIV
por: Regoes, Roland R., et al.
Publicado: (2014)

Impact of Direct-Acting Antivirals on the Burden of HCV Infection Among Persons Who Inject Drugs and Men Who Have Sex With Men in the Swiss HIV Cohort Study
por: Salazar-Vizcaya, Luisa, et al.
Publicado: (2018)

Mortality from suicide among people living with HIV and the general Swiss population: 1988‐2017
por: Ruffieux, Yann, et al.
Publicado: (2019)

The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
por: Surial, Bernard, et al.
Publicado: (2021)

Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study
por: Fehr, Jan, et al.
Publicado: (2011)

Prevalence of HIV-1 drug resistance mutations in proviral DNA in the Swiss HIV Cohort Study, a retrospective study from 1995 to 2018
por: Jaha, Bashkim, et al.
Publicado: (2023)

Early Antiretroviral Therapy During Primary HIV-1 Infection Results in a Transient Reduction of the Viral Setpoint upon Treatment Interruption
por: von Wyl, Viktor, et al.
Publicado: (2011)

CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART
por: Sauter, Rafael, et al.
Publicado: (2016)

HCV Genetic Diversity Can Be Used to Infer Infection Recency and Time since Infection
por: Carlisle, Louisa A., et al.
Publicado: (2020)

Risk Factors and Incidence of Sexually Transmitted Infections in the Swiss HIV Cohort Study
por: Bosetti, Davide, et al.
Publicado: (2022)

Determinants of Sustained Viral Suppression in HIV-Infected Patients with Self-Reported Poor Adherence to Antiretroviral Therapy
por: Glass, Tracy R., et al.
Publicado: (2012)

Impact of scaling up dolutegravir on antiretroviral resistance in South Africa: A modeling study
por: Hauser, Anthony, et al.
Publicado: (2020)

Diagnosis of latent tuberculosis infection is associated with reduced HIV viral load and lower risk for opportunistic infections in people living with HIV
por: Kusejko, Katharina, et al.
Publicado: (2020)

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity
por: Bertels, Frederic, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ku6sdt69gbpiqblbsonqilm0mh