NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10 cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves impaired endothelium-dependent vasodilation through reactive oxygen species (ROS) formation. Indeed, ROS forming NADPH...

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Detalles Bibliográficos
Autores principales: Elbatreek, Mahmoud H., Sadegh, Sepideh, Anastasi, Elisa, Guney, Emre, Nogales, Cristian, Kacprowski, Tim, Hassan, Ahmed A., Teubner, Andreas, Huang, Po-Hsun, Hsu, Chien-Yi, Schiffers, Paul M. H., Janssen, Ger M., Kleikers, Pamela W. M., Wipat, Anil, Baumbach, Jan, De Mey, Jo G. R., Schmidt, Harald H. H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654809/
https://www.ncbi.nlm.nih.gov/pubmed/33170835
http://dx.doi.org/10.1371/journal.pbio.3000885

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