Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

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Containment of the COVID-19 pandemic requires reducing viral transmission. SARS-CoV-2 infection is initiated by membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. We have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step...

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Detalles Bibliográficos
Autores principales: de Vries, Rory D., Schmitz, Katharina S., Bovier, Francesca T., Noack, Danny, Haagmans, Bart L., Biswas, Sudipta, Rockx, Barry, Gellman, Samuel H., Alabi, Christopher A., de Swart, Rik L., Moscona, Anne, Porotto, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654853/
https://www.ncbi.nlm.nih.gov/pubmed/33173865
http://dx.doi.org/10.1101/2020.11.04.361154
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