Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality

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Viruses co-opt host proteins to carry out their lifecycle. Repurposed host proteins may thus become functionally compromised; a situation analogous to a loss-of-function mutation. We term such host proteins viral-induced hypomorphs. Cells bearing cancer driver loss-of-function mutations have success...

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Detalles Bibliográficos
Autores principales: Navare, Arti T, Mast, Fred D, Olivier, Jean Paul, Bertomeu, Thierry, Neal, Maxwell, Carpp, Lindsay N, Kaushansky, Alexis, Coulombe-Huntington, Jasmin, Tyers, Mike, Aitchison, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654857/
https://www.ncbi.nlm.nih.gov/pubmed/33173868
http://dx.doi.org/10.1101/2020.10.12.336487

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