Cargando…

Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach

Children born extremely preterm (EPT, <28 weeks gestation) are at risk for delays in development, including language. We use fMRI-constrained magnetoencephalography (MEG) during a verb generation task to assess the extent and functional connectivity (phase locking value, or PLV) of language netwo...

Descripción completa

Detalles Bibliográficos
Autores principales: Barnes-Davis, Maria E., Merhar, Stephanie L., Holland, Scott K., Parikh, Nehal A., Kadis, Darren S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654860/
https://www.ncbi.nlm.nih.gov/pubmed/33173877
http://dx.doi.org/10.1101/2020.10.30.20222448
_version_ 1783608133077172224
author Barnes-Davis, Maria E.
Merhar, Stephanie L.
Holland, Scott K.
Parikh, Nehal A.
Kadis, Darren S.
author_facet Barnes-Davis, Maria E.
Merhar, Stephanie L.
Holland, Scott K.
Parikh, Nehal A.
Kadis, Darren S.
author_sort Barnes-Davis, Maria E.
collection PubMed
description Children born extremely preterm (EPT, <28 weeks gestation) are at risk for delays in development, including language. We use fMRI-constrained magnetoencephalography (MEG) during a verb generation task to assess the extent and functional connectivity (phase locking value, or PLV) of language networks in a large cohort of EPT children and their term comparisons (TC). 73 participants, aged 4 to 6 years, were enrolled (42 TC, 31 EPT). There were no significant group differences in age, sex, race, ethnicity, parental education, or family income. There were significant group differences in expressive language scores (p<0.05). Language representation was not significantly different between groups on fMRI, with task-specific activation involving bilateral temporal and left inferior frontal cortex. There were group differences in functional connectivity seen in MEG. To identify a possible subnetwork contributing to focal spectral differences in connectivity, we ran Network Based Statistics analyses. For both beta (20–25 Hz) and gamma (61–70 Hz) bands, we observed a subnetwork showing hyperconnectivity in the EPT group (p<0.05). Network strength was computed for the beta and gamma subnetworks and assessed for correlation with language performance. For the EPT group, exclusively, strength of the subnetwork identified in the gamma frequency band was positively correlated with expressive language scores (r=0.318, p<0.05). Thus, interhemispheric hyperconnectivity is positively related to language for EPT children and might represent a marker for resiliency in this population.
format Online
Article
Text
id pubmed-7654860
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Cold Spring Harbor Laboratory
record_format MEDLINE/PubMed
spelling pubmed-76548602020-11-11 Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach Barnes-Davis, Maria E. Merhar, Stephanie L. Holland, Scott K. Parikh, Nehal A. Kadis, Darren S. medRxiv Article Children born extremely preterm (EPT, <28 weeks gestation) are at risk for delays in development, including language. We use fMRI-constrained magnetoencephalography (MEG) during a verb generation task to assess the extent and functional connectivity (phase locking value, or PLV) of language networks in a large cohort of EPT children and their term comparisons (TC). 73 participants, aged 4 to 6 years, were enrolled (42 TC, 31 EPT). There were no significant group differences in age, sex, race, ethnicity, parental education, or family income. There were significant group differences in expressive language scores (p<0.05). Language representation was not significantly different between groups on fMRI, with task-specific activation involving bilateral temporal and left inferior frontal cortex. There were group differences in functional connectivity seen in MEG. To identify a possible subnetwork contributing to focal spectral differences in connectivity, we ran Network Based Statistics analyses. For both beta (20–25 Hz) and gamma (61–70 Hz) bands, we observed a subnetwork showing hyperconnectivity in the EPT group (p<0.05). Network strength was computed for the beta and gamma subnetworks and assessed for correlation with language performance. For the EPT group, exclusively, strength of the subnetwork identified in the gamma frequency band was positively correlated with expressive language scores (r=0.318, p<0.05). Thus, interhemispheric hyperconnectivity is positively related to language for EPT children and might represent a marker for resiliency in this population. Cold Spring Harbor Laboratory 2020-11-04 /pmc/articles/PMC7654860/ /pubmed/33173877 http://dx.doi.org/10.1101/2020.10.30.20222448 Text en http://creativecommons.org/licenses/by-nd/4.0/It is made available under a CC-BY-ND 4.0 International license (http://creativecommons.org/licenses/by-nd/4.0/) .
spellingShingle Article
Barnes-Davis, Maria E.
Merhar, Stephanie L.
Holland, Scott K.
Parikh, Nehal A.
Kadis, Darren S.
Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach
title Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach
title_full Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach
title_fullStr Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach
title_full_unstemmed Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach
title_short Extremely Preterm Children Demonstrate Interhemispheric Hyperconnectivity During Verb Generation: a Multimodal Approach
title_sort extremely preterm children demonstrate interhemispheric hyperconnectivity during verb generation: a multimodal approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654860/
https://www.ncbi.nlm.nih.gov/pubmed/33173877
http://dx.doi.org/10.1101/2020.10.30.20222448
work_keys_str_mv AT barnesdavismariae extremelypretermchildrendemonstrateinterhemispherichyperconnectivityduringverbgenerationamultimodalapproach
AT merharstephaniel extremelypretermchildrendemonstrateinterhemispherichyperconnectivityduringverbgenerationamultimodalapproach
AT hollandscottk extremelypretermchildrendemonstrateinterhemispherichyperconnectivityduringverbgenerationamultimodalapproach
AT parikhnehala extremelypretermchildrendemonstrateinterhemispherichyperconnectivityduringverbgenerationamultimodalapproach
AT kadisdarrens extremelypretermchildrendemonstrateinterhemispherichyperconnectivityduringverbgenerationamultimodalapproach