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Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2
Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the gene expression of viral entry proteins ACE2 and TMPRSS2, and host transcriptional responses to SARS-CoV-2...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654875/ https://www.ncbi.nlm.nih.gov/pubmed/33173861 http://dx.doi.org/10.21203/rs.3.rs-100914/v2 |
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author | Sun, Mengying Shankar, Rama Ko, Meehyun Chang, Christopher Daniel Yeh, Shan-Ju Li, Shilong Liu, Ke Zhou, Guoli Xing, Jing VanVelsen, Austin VanVelsen, Tyler Paithankar, Shreya Feng, Benjamin Y. Young, Krista Strug, Michael Turco, Lauren Wang, Zichen Schadt, Eric Chen, Rong Li, Xiaohong Oskotsky, Tomiko Sirota, Marina Glicksberg, Benjamin S. Nadkarni, Girish N. Moeser, Adam J. Li, Li Kim, Seungtaek Zhou, Jiayu Chen, Bin |
author_facet | Sun, Mengying Shankar, Rama Ko, Meehyun Chang, Christopher Daniel Yeh, Shan-Ju Li, Shilong Liu, Ke Zhou, Guoli Xing, Jing VanVelsen, Austin VanVelsen, Tyler Paithankar, Shreya Feng, Benjamin Y. Young, Krista Strug, Michael Turco, Lauren Wang, Zichen Schadt, Eric Chen, Rong Li, Xiaohong Oskotsky, Tomiko Sirota, Marina Glicksberg, Benjamin S. Nadkarni, Girish N. Moeser, Adam J. Li, Li Kim, Seungtaek Zhou, Jiayu Chen, Bin |
author_sort | Sun, Mengying |
collection | PubMed |
description | Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the gene expression of viral entry proteins ACE2 and TMPRSS2, and host transcriptional responses to SARS-CoV-2 through large-scale analysis of genomic and clinical data. We first compiled 220,000 human gene expression profiles from three databases and completed the meta-information through machine learning and manual annotation. Large scale analysis of these profiles indicated that male samples show higher expression levels of ACE2 and TMPRSS2 than female samples, especially in the older group (>60 years) and in the kidney. Subsequent analysis of 6,031 COVID-19 patients at Mount Sinai Health System revealed that men have significantly higher creatinine levels, an indicator of impaired kidney function. Further analysis of 782 COVID-19 patient gene expression profiles taken from upper airway and blood suggested men and women present distinct expression changes. Computational deconvolution analysis of these profiles revealed male COVID-19 patients have enriched kidney-specific mesangial cells in blood compared to healthy patients. Together, this study suggests biological differences in the kidney between sexes may contribute to sex disparity in COVID-19. |
format | Online Article Text |
id | pubmed-7654875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Journal Experts |
record_format | MEDLINE/PubMed |
spelling | pubmed-76548752020-11-11 Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2 Sun, Mengying Shankar, Rama Ko, Meehyun Chang, Christopher Daniel Yeh, Shan-Ju Li, Shilong Liu, Ke Zhou, Guoli Xing, Jing VanVelsen, Austin VanVelsen, Tyler Paithankar, Shreya Feng, Benjamin Y. Young, Krista Strug, Michael Turco, Lauren Wang, Zichen Schadt, Eric Chen, Rong Li, Xiaohong Oskotsky, Tomiko Sirota, Marina Glicksberg, Benjamin S. Nadkarni, Girish N. Moeser, Adam J. Li, Li Kim, Seungtaek Zhou, Jiayu Chen, Bin Res Sq Article Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the gene expression of viral entry proteins ACE2 and TMPRSS2, and host transcriptional responses to SARS-CoV-2 through large-scale analysis of genomic and clinical data. We first compiled 220,000 human gene expression profiles from three databases and completed the meta-information through machine learning and manual annotation. Large scale analysis of these profiles indicated that male samples show higher expression levels of ACE2 and TMPRSS2 than female samples, especially in the older group (>60 years) and in the kidney. Subsequent analysis of 6,031 COVID-19 patients at Mount Sinai Health System revealed that men have significantly higher creatinine levels, an indicator of impaired kidney function. Further analysis of 782 COVID-19 patient gene expression profiles taken from upper airway and blood suggested men and women present distinct expression changes. Computational deconvolution analysis of these profiles revealed male COVID-19 patients have enriched kidney-specific mesangial cells in blood compared to healthy patients. Together, this study suggests biological differences in the kidney between sexes may contribute to sex disparity in COVID-19. American Journal Experts 2020-12-31 /pmc/articles/PMC7654875/ /pubmed/33173861 http://dx.doi.org/10.21203/rs.3.rs-100914/v2 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Sun, Mengying Shankar, Rama Ko, Meehyun Chang, Christopher Daniel Yeh, Shan-Ju Li, Shilong Liu, Ke Zhou, Guoli Xing, Jing VanVelsen, Austin VanVelsen, Tyler Paithankar, Shreya Feng, Benjamin Y. Young, Krista Strug, Michael Turco, Lauren Wang, Zichen Schadt, Eric Chen, Rong Li, Xiaohong Oskotsky, Tomiko Sirota, Marina Glicksberg, Benjamin S. Nadkarni, Girish N. Moeser, Adam J. Li, Li Kim, Seungtaek Zhou, Jiayu Chen, Bin Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2 |
title | Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2 |
title_full | Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2 |
title_fullStr | Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2 |
title_full_unstemmed | Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2 |
title_short | Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2 |
title_sort | sex differences in viral entry protein expression and host transcript responses to sars-cov-2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654875/ https://www.ncbi.nlm.nih.gov/pubmed/33173861 http://dx.doi.org/10.21203/rs.3.rs-100914/v2 |
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