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Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand
BACKGROUND: Given the lack of specific antiviral drugs and effective vaccine for dengue infection, factors such as host nutritional status that may alter disease progression require investigation. This study examined the relationship between baseline nutritional status and severity of dengue infecti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654944/ https://www.ncbi.nlm.nih.gov/pubmed/32773668 http://dx.doi.org/10.1097/INF.0000000000002839 |
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author | Maneerattanasak, Sarunya Suwanbamrung, Charuai |
author_facet | Maneerattanasak, Sarunya Suwanbamrung, Charuai |
author_sort | Maneerattanasak, Sarunya |
collection | PubMed |
description | BACKGROUND: Given the lack of specific antiviral drugs and effective vaccine for dengue infection, factors such as host nutritional status that may alter disease progression require investigation. This study examined the relationship between baseline nutritional status and severity of dengue infection in pediatric patients. METHODS: Data from dengue patients 1–14 years of age treated at four hospitals in southern Thailand (2017–2018) were reviewed. Dengue infection was classified as dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Children’s nutritional status was assessed based on international and national growth charts. Binary logistic regression was used to identify factors associated with dengue severity and malnutrition. RESULTS: Overall, 248, 281 and 43 patients had dengue fever, dengue hemorrhagic fever and dengue shock syndrome, respectively. Overweight was associated with increased risk of dengue severity [odds ratio (OR) = 1.76, 95% confidence interval (CI): 1.13–2.75, P = 0.012; OR = 1.84, 95% CI: 1.09–3.09, P = 0.022, per international and national growth criteria, respectively). Stunting was associated with decreased risk of dengue severity (OR = 0.54, 95% CI: 0.33–0.88, P = 0.013; OR = 0.61, 95% CI: 0.39–0.95, P = 0.030, per international and national growth criteria, respectively). Being overweight was significantly and positively associated with levels of hemoglobin >14 g/dL, hematocrit >42%, hemoconcentration ≥20% and platelet count ≤50,000/mm(3), whereas being stunted was significantly and negatively associated with levels of hemoglobin >14 g/dL and hematocrit >42%. CONCLUSIONS: These findings support a hypothesis that malnutrition might influence the severity of dengue infection through host immune response. Overweight children with dengue infections should be closely observed for early signs of severe dengue infection. |
format | Online Article Text |
id | pubmed-7654944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-76549442020-11-16 Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand Maneerattanasak, Sarunya Suwanbamrung, Charuai Pediatr Infect Dis J Original Studies BACKGROUND: Given the lack of specific antiviral drugs and effective vaccine for dengue infection, factors such as host nutritional status that may alter disease progression require investigation. This study examined the relationship between baseline nutritional status and severity of dengue infection in pediatric patients. METHODS: Data from dengue patients 1–14 years of age treated at four hospitals in southern Thailand (2017–2018) were reviewed. Dengue infection was classified as dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Children’s nutritional status was assessed based on international and national growth charts. Binary logistic regression was used to identify factors associated with dengue severity and malnutrition. RESULTS: Overall, 248, 281 and 43 patients had dengue fever, dengue hemorrhagic fever and dengue shock syndrome, respectively. Overweight was associated with increased risk of dengue severity [odds ratio (OR) = 1.76, 95% confidence interval (CI): 1.13–2.75, P = 0.012; OR = 1.84, 95% CI: 1.09–3.09, P = 0.022, per international and national growth criteria, respectively). Stunting was associated with decreased risk of dengue severity (OR = 0.54, 95% CI: 0.33–0.88, P = 0.013; OR = 0.61, 95% CI: 0.39–0.95, P = 0.030, per international and national growth criteria, respectively). Being overweight was significantly and positively associated with levels of hemoglobin >14 g/dL, hematocrit >42%, hemoconcentration ≥20% and platelet count ≤50,000/mm(3), whereas being stunted was significantly and negatively associated with levels of hemoglobin >14 g/dL and hematocrit >42%. CONCLUSIONS: These findings support a hypothesis that malnutrition might influence the severity of dengue infection through host immune response. Overweight children with dengue infections should be closely observed for early signs of severe dengue infection. Lippincott Williams & Wilkins 2020-08-10 2020-12 /pmc/articles/PMC7654944/ /pubmed/32773668 http://dx.doi.org/10.1097/INF.0000000000002839 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Original Studies Maneerattanasak, Sarunya Suwanbamrung, Charuai Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand |
title | Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand |
title_full | Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand |
title_fullStr | Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand |
title_full_unstemmed | Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand |
title_short | Impact of Nutritional Status on the Severity of Dengue Infection Among Pediatric Patients in Southern Thailand |
title_sort | impact of nutritional status on the severity of dengue infection among pediatric patients in southern thailand |
topic | Original Studies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654944/ https://www.ncbi.nlm.nih.gov/pubmed/32773668 http://dx.doi.org/10.1097/INF.0000000000002839 |
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