Role of tumor microenvironment in the efficacy of BCG therapy

Despite its significant overall efficacy, BCG fails to benefit a substantial proportion of bladder cancer (BlCa) patients. Here, we review recent data highlighting the role of tumor microenvironment (TME) in limiting antitumoral activity of BCG treatment and emerging opportunities to target TME to e...

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Autores principales: Ibrahim, Omar M, Pandey, Ravindra K, Chatta, Gurkamal, Kalinski, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654968/
https://www.ncbi.nlm.nih.gov/pubmed/33178990
http://dx.doi.org/10.15761/tr.1000170
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author Ibrahim, Omar M
Pandey, Ravindra K
Chatta, Gurkamal
Kalinski, Pawel
author_facet Ibrahim, Omar M
Pandey, Ravindra K
Chatta, Gurkamal
Kalinski, Pawel
author_sort Ibrahim, Omar M
collection PubMed
description Despite its significant overall efficacy, BCG fails to benefit a substantial proportion of bladder cancer (BlCa) patients. Here, we review recent data highlighting the role of tumor microenvironment (TME) in limiting antitumoral activity of BCG treatment and emerging opportunities to target TME to enhance the overall outcomes in BCG-treated BlCa patients.
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spelling pubmed-76549682020-11-10 Role of tumor microenvironment in the efficacy of BCG therapy Ibrahim, Omar M Pandey, Ravindra K Chatta, Gurkamal Kalinski, Pawel Trends Res Article Despite its significant overall efficacy, BCG fails to benefit a substantial proportion of bladder cancer (BlCa) patients. Here, we review recent data highlighting the role of tumor microenvironment (TME) in limiting antitumoral activity of BCG treatment and emerging opportunities to target TME to enhance the overall outcomes in BCG-treated BlCa patients. 2020-08-17 2020-10 /pmc/articles/PMC7654968/ /pubmed/33178990 http://dx.doi.org/10.15761/tr.1000170 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Ibrahim, Omar M
Pandey, Ravindra K
Chatta, Gurkamal
Kalinski, Pawel
Role of tumor microenvironment in the efficacy of BCG therapy
title Role of tumor microenvironment in the efficacy of BCG therapy
title_full Role of tumor microenvironment in the efficacy of BCG therapy
title_fullStr Role of tumor microenvironment in the efficacy of BCG therapy
title_full_unstemmed Role of tumor microenvironment in the efficacy of BCG therapy
title_short Role of tumor microenvironment in the efficacy of BCG therapy
title_sort role of tumor microenvironment in the efficacy of bcg therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654968/
https://www.ncbi.nlm.nih.gov/pubmed/33178990
http://dx.doi.org/10.15761/tr.1000170
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AT chattagurkamal roleoftumormicroenvironmentintheefficacyofbcgtherapy
AT kalinskipawel roleoftumormicroenvironmentintheefficacyofbcgtherapy

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