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Crystal structure-guided design of berberine-based novel chitinase inhibitors

Glycoside hydrolase family 18 (GH18) chitinases play an important role in various organisms ranging from bacteria to mammals. Chitinase inhibitors have potential applications as pesticides, fungicides, and anti-asthmatics. Berberine, a plant-derived isoquinoline alkaloid, was previously reported to...

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Detalles Bibliográficos
Autores principales: Chen, Lei, Zhu, Ling, Chen, Jinli, Chen, Wei, Qian, Xuhong, Yang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655067/
https://www.ncbi.nlm.nih.gov/pubmed/33167737
http://dx.doi.org/10.1080/14756366.2020.1837123