Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

Osteoarthritis (OA) is one of the most painful and widespread chronic degenerative joint diseases and is characterized by destructed articular cartilage and inflamed joints. Previously, our findings indicated that circular RNA ciRS-7 (ciRS-7)/microRNA 7 (miR-7) axis is abnormally expressed in OA, an...

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Detalles Bibliográficos
Autores principales: Zhou, Xindie, Li, Jin, Zhou, Yuanshuai, Yang, Zhicheng, Yang, Haoyu, Li, Dong, Zhang, Junjie, Zhang, Yi, Xu, Nanwei, Huang, Yong, Jiang, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655186/
https://www.ncbi.nlm.nih.gov/pubmed/33099538
http://dx.doi.org/10.18632/aging.103731

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