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Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis
Osteoarthritis (OA) is one of the most painful and widespread chronic degenerative joint diseases and is characterized by destructed articular cartilage and inflamed joints. Previously, our findings indicated that circular RNA ciRS-7 (ciRS-7)/microRNA 7 (miR-7) axis is abnormally expressed in OA, an...
Autores principales: | Zhou, Xindie, Li, Jin, Zhou, Yuanshuai, Yang, Zhicheng, Yang, Haoyu, Li, Dong, Zhang, Junjie, Zhang, Yi, Xu, Nanwei, Huang, Yong, Jiang, Lifeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655186/ https://www.ncbi.nlm.nih.gov/pubmed/33099538 http://dx.doi.org/10.18632/aging.103731 |
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