Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells

This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling mole...

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Detalles Bibliográficos
Autores principales: Baik, Ji Sue, Seo, You Na, Yi, Joo Mi, Rhee, Man Hee, Park, Moon-Taek, Kim, Sung Dae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655488/
https://www.ncbi.nlm.nih.gov/pubmed/33192128
http://dx.doi.org/10.1016/j.jgr.2020.01.006
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author Baik, Ji Sue
Seo, You Na
Yi, Joo Mi
Rhee, Man Hee
Park, Moon-Taek
Kim, Sung Dae
author_facet Baik, Ji Sue
Seo, You Na
Yi, Joo Mi
Rhee, Man Hee
Park, Moon-Taek
Kim, Sung Dae
author_sort Baik, Ji Sue
collection PubMed
description This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.
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spelling pubmed-76554882020-11-13 Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells Baik, Ji Sue Seo, You Na Yi, Joo Mi Rhee, Man Hee Park, Moon-Taek Kim, Sung Dae J Ginseng Res Technical Note This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages. Elsevier 2020-11 2020-01-31 /pmc/articles/PMC7655488/ /pubmed/33192128 http://dx.doi.org/10.1016/j.jgr.2020.01.006 Text en © 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Technical Note
Baik, Ji Sue
Seo, You Na
Yi, Joo Mi
Rhee, Man Hee
Park, Moon-Taek
Kim, Sung Dae
Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
title Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
title_full Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
title_fullStr Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
title_full_unstemmed Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
title_short Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
title_sort ginsenoside-rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated j774a.1 macrophages and suppresses phenotypic variation in ct26 colon cancer cells
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655488/
https://www.ncbi.nlm.nih.gov/pubmed/33192128
http://dx.doi.org/10.1016/j.jgr.2020.01.006
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