Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

Oncogenic mutations in RAS genes, like KRAS(G12D) or NRAS(G12D), trap Ras in the active state and cause myeloproliferative disorder and T cell leukemia (T-ALL) when induced in the bone marrow via Mx1CRE. The RAS exchange factor RASGRP1 is frequently overexpressed in T-ALL patients. In T-ALL cell lin...

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Detalles Bibliográficos
Autores principales: Karra, Laila, Romero-Moya, Damia, Ksionda, Olga, Krush, Milana, Gu, Zhaohui, Mues, Marsilius, Depeille, Philippe, Mullighan, Charles, Roose, Jeroen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655557/
https://www.ncbi.nlm.nih.gov/pubmed/32989257
http://dx.doi.org/10.1038/s41388-020-01469-8

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