Cargando…

Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts

Acrylamide is a suspected human carcinogen formed during high-temperature cooking of starch-rich foods. It is metabolised by cytochrome P450 2E1 to its reactive metabolite glycidamide, which forms pre-mutagenic DNA adducts. Using the human TP53 knock-in (Hupki) mouse embryo fibroblasts (HUFs) immort...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hölzl-Armstrong, Lisa, Kucab, Jill E., Moody, Sarah, Zwart, Edwin P., Loutkotová, Lucie, Duffy, Veronica, Luijten, Mirjam, Gamboa da Costa, Gonçalo, Stratton, Michael R., Phillips, David H., Arlt, Volker M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Genotoxicity and Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655573/ https://www.ncbi.nlm.nih.gov/pubmed/32886187 http://dx.doi.org/10.1007/s00204-020-02878-0

Ejemplares similares

The effect of alkyl substitution on the oxidative metabolism and mutagenicity of phenanthrene
por: Wang, Danlei, et al.
Publicado: (2022)

Synthesis and in vitro characterization of the genotoxic, mutagenic and cell-transforming potential of nitrosylated heme
por: Kostka, Tina, et al.
Publicado: (2020)

PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity
por: Fischer, Jan M. F., et al.
Publicado: (2017)

BPDE-induced genotoxicity: relationship between DNA adducts, mutagenicity in the in vitro PIG-A assay, and the transcriptional response to DNA damage in TK6 cells
por: Piberger, Ann Liza, et al.
Publicado: (2017)

Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway
por: Abbass, Mustafa, et al.
Publicado: (2021)

Characterising Mutational Spectra of Carcinogens in the Tumour Suppressor Gene TP53 Using Human TP53 Knock-in (Hupki) Mouse Embryo Fibroblasts
por: Hölzl-Armstrong, Lisa, et al.
Publicado: (2019)

Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene
por: Long, Alexandra S., et al.
Publicado: (2017)

Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene
por: Shi, Q., et al.
Publicado: (2015)

Cytochrome b(5) impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b(5)/P450 reductase null (HBRN) mice
por: Reed, Lindsay, et al.
Publicado: (2018)

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro
por: Sborchia, Mateja, et al.
Publicado: (2019)

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone
por: Arlt, Volker M., et al.
Publicado: (2016)

Bisphenol A-glycidyl methacrylate induces a broad spectrum of DNA damage in human lymphocytes
por: Drozdz, Kinga, et al.
Publicado: (2010)

The benzene metabolite para-benzoquinone is genotoxic in human, phorbol-12-acetate-13-myristate induced, peripheral blood mononuclear cells at low concentrations
por: Westphal, Götz Alexander, et al.
Publicado: (2009)

Genotoxic properties of XLR-11, a widely consumed synthetic cannabinoid, and of the benzoyl indole RCS-4
por: Ferk, Franziska, et al.
Publicado: (2016)

Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer
por: Malik, Durr-e-shahwar, et al.
Publicado: (2018)

Environmentally prevalent polycyclic aromatic hydrocarbons can elicit co-carcinogenic properties in an in vitro murine lung epithelial cell model
por: Bauer, Alison K., et al.
Publicado: (2017)

Mesenchyme-derived factors enhance preneoplastic growth by non-genotoxic carcinogens in rat liver
por: Nejabat, Marzieh, et al.
Publicado: (2017)

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells
por: Wilde, Eleanor C., et al.
Publicado: (2017)

Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?
por: Waldherr, Monika, et al.
Publicado: (2017)

The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines
por: Kolbinger, Fiona R., et al.
Publicado: (2018)

Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human
por: Pognan, Francois, et al.
Publicado: (2018)

Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells
por: Malik, Durr-e-shahwar, et al.
Publicado: (2018)

Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells
por: Russo, Chiara, et al.
Publicado: (2018)

Acidic cellular microenvironment modifies carcinogen-induced DNA damage and repair
por: Shi, Q., et al.
Publicado: (2016)

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and promote human breast cell carcinogenesis in vitro
por: Pierozan, Paula, et al.
Publicado: (2020)

Following the adverse outcome pathway from micronucleus to cancer using H2B-eGFP transgenic healthy stem cells
por: Hölzel, Bastian Niklas, et al.
Publicado: (2020)

Long-term fate of etoposide-induced micronuclei and micronucleated cells in Hela-H2B-GFP cells
por: Reimann, Hauke, et al.
Publicado: (2020)

Gut microbiota and undigested food constituents modify toxin composition and suppress the genotoxicity of a naturally occurring mixture of Alternaria toxins in vitro
por: Crudo, Francesco, et al.
Publicado: (2020)

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix
por: Yang, Shuo, et al.
Publicado: (2020)

Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells
por: Rutz, Lukas, et al.
Publicado: (2020)

Salivary leucocytes as suitable biomatrix for the comet assay in human biomonitoring studies
por: Fernández-Bertólez, Natalia, et al.
Publicado: (2021)

The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals
por: Marchetti, Francesco, et al.
Publicado: (2021)

A fast and reliable method for monitoring genomic instability in the model organism Caenorhabditis elegans
por: Nicolai, Merle Marie, et al.
Publicado: (2021)

Effect of cryopreservation on DNA damage and DNA repair activity in human blood samples in the comet assay
por: Bankoglu, Ezgi Eyluel, et al.
Publicado: (2021)

Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning
por: Wills, John W., et al.
Publicado: (2021)

Validation of the in vitro comet assay for DNA cross-links and altered bases detection
por: Muruzabal, Damián, et al.
Publicado: (2021)

Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells
por: Müller, Lena, et al.
Publicado: (2021)

Cell survival after DNA damage in the comet assay
por: Bankoglu, Ezgi Eyluel, et al.
Publicado: (2021)

Feeding Brassica vegetables to rats leads to the formation of characteristic DNA adducts (from 1-methoxy-3-indolylmethyl glucosinolate) in many tissues
por: Glatt, Hansruedi, et al.
Publicado: (2022)

Influence of breast cancer risk factors on proliferation and DNA damage in human breast glandular tissues: role of intracellular estrogen levels, oxidative stress and estrogen biotransformation
por: Wunder, Juliane, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qasa02o4eeksjk83norsqorodc