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PI3Kγ Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition—Moving Towards Cell Specific PI3K Targeting?

Mast cells are the major effector cells in immunoglobulin E (IgE)-mediated allergy. The high affinity IgE receptor FcεRI, as well as G protein-coupled receptors (GPCRs) on the mast cell surface signals to phosphoinositide 3-kinase γ (PI3Kγ) to initiate degranulation, cytokine release, and chemotaxis...

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Detalles Bibliográficos
Autores principales:	Jin, Julie R., Gogvadze, Elena, Xavier, Ana R., Bohnacker, Thomas, Voelzmann, Jan, Wymann, Matthias P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655736/ https://www.ncbi.nlm.nih.gov/pubmed/33193405 http://dx.doi.org/10.3389/fimmu.2020.585070

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