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Aortic “Disease-in-a-Dish”: Mechanistic Insights and Drug Development Using iPSC-Based Disease Modeling

Thoracic aortic diseases, whether sporadic or due to a genetic disorder such as Marfan syndrome, lack effective medical therapies, with limited translation of treatments that are highly successful in mouse models into the clinic. Patient-derived induced pluripotent stem cells (iPSCs) offer the oppor...

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Detalles Bibliográficos
Autores principales:	Davaapil, Hongorzul, Shetty, Deeti K., Sinha, Sanjay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655792/ https://www.ncbi.nlm.nih.gov/pubmed/33195187 http://dx.doi.org/10.3389/fcell.2020.550504

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