TGF-β1 Suppresses Proliferation and Induces Differentiation in Human iPSC Neural in vitro Models

Persistent neural stem cell (NSC) proliferation is, among others, a hallmark of immaturity in human induced pluripotent stem cell (hiPSC)-based neural models. TGF-β1 is known to regulate NSCs in vivo during embryonic development in rodents. Here we examined the role of TGF-β1 as a potential candidat...

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Detalles Bibliográficos
Autores principales: Izsak, Julia, Vizlin-Hodzic, Dzeneta, Iljin, Margarita, Strandberg, Joakim, Jadasz, Janusz, Olsson Bontell, Thomas, Theiss, Stephan, Hanse, Eric, Ågren, Hans, Funa, Keiko, Illes, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655796/
https://www.ncbi.nlm.nih.gov/pubmed/33195202
http://dx.doi.org/10.3389/fcell.2020.571332

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