A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia

Elderly patients aged 65 or older with acute myeloid leukemia (AML) have poor prognosis. The risk stratification based on genetic alteration has been proposed in national comprehensive cancer network (NCCN) guideline but its efficacy was not well verified especially in real world elderly patients. T...

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Autores principales: Senjo, Hajime, Onozawa, Masahiro, Hidaka, Daisuke, Yokoyama, Shota, Yamamoto, Satoshi, Tsutsumi, Yutaka, Haseyama, Yoshihito, Nagashima, Takahiro, Mori, Akio, Ota, Shuichi, Sakai, Hajime, Ishihara, Toshimichi, Miyagishima, Takuto, Kakinoki, Yasutaka, Kurosawa, Mitsutoshi, Kobayashi, Hajime, Iwasaki, Hiroshi, Hashimoto, Daigo, Kondo, Takeshi, Teshima, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655799/
https://www.ncbi.nlm.nih.gov/pubmed/33173122
http://dx.doi.org/10.1038/s41598-020-76250-8
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author Senjo, Hajime
Onozawa, Masahiro
Hidaka, Daisuke
Yokoyama, Shota
Yamamoto, Satoshi
Tsutsumi, Yutaka
Haseyama, Yoshihito
Nagashima, Takahiro
Mori, Akio
Ota, Shuichi
Sakai, Hajime
Ishihara, Toshimichi
Miyagishima, Takuto
Kakinoki, Yasutaka
Kurosawa, Mitsutoshi
Kobayashi, Hajime
Iwasaki, Hiroshi
Hashimoto, Daigo
Kondo, Takeshi
Teshima, Takanori
author_facet Senjo, Hajime
Onozawa, Masahiro
Hidaka, Daisuke
Yokoyama, Shota
Yamamoto, Satoshi
Tsutsumi, Yutaka
Haseyama, Yoshihito
Nagashima, Takahiro
Mori, Akio
Ota, Shuichi
Sakai, Hajime
Ishihara, Toshimichi
Miyagishima, Takuto
Kakinoki, Yasutaka
Kurosawa, Mitsutoshi
Kobayashi, Hajime
Iwasaki, Hiroshi
Hashimoto, Daigo
Kondo, Takeshi
Teshima, Takanori
author_sort Senjo, Hajime
collection PubMed
description Elderly patients aged 65 or older with acute myeloid leukemia (AML) have poor prognosis. The risk stratification based on genetic alteration has been proposed in national comprehensive cancer network (NCCN) guideline but its efficacy was not well verified especially in real world elderly patients. The nutritional status assessment using controlling nutritional status (CONUT) score is a prognostic biomarker in elderly patients with solid tumors but was not examined in elderly AML patients. We performed prospective analysis of genetic alterations of 174 patients aged 65 or older with newly diagnosed AML treated without hematopoietic stem cell transplantation (HSCT) and developed simplified CONUT (sCONUT) score by eliminating total lymphocyte count from the items to adapt AML patients. In this cohort, both the NCCN 2017 risk group and sCONUT score successfully stratified the overall survival (OS) of the elderly patients. A multivariable analysis demonstrated that adverse group in NCCN 2017 and high sCONUT score were independently associated with poor 2-year OS. Both risk stratification based on NCCN 2017 and sCONUT score predict prognosis in the elderly patients with newly diagnosed AML.
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spelling pubmed-76557992020-11-12 A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia Senjo, Hajime Onozawa, Masahiro Hidaka, Daisuke Yokoyama, Shota Yamamoto, Satoshi Tsutsumi, Yutaka Haseyama, Yoshihito Nagashima, Takahiro Mori, Akio Ota, Shuichi Sakai, Hajime Ishihara, Toshimichi Miyagishima, Takuto Kakinoki, Yasutaka Kurosawa, Mitsutoshi Kobayashi, Hajime Iwasaki, Hiroshi Hashimoto, Daigo Kondo, Takeshi Teshima, Takanori Sci Rep Article Elderly patients aged 65 or older with acute myeloid leukemia (AML) have poor prognosis. The risk stratification based on genetic alteration has been proposed in national comprehensive cancer network (NCCN) guideline but its efficacy was not well verified especially in real world elderly patients. The nutritional status assessment using controlling nutritional status (CONUT) score is a prognostic biomarker in elderly patients with solid tumors but was not examined in elderly AML patients. We performed prospective analysis of genetic alterations of 174 patients aged 65 or older with newly diagnosed AML treated without hematopoietic stem cell transplantation (HSCT) and developed simplified CONUT (sCONUT) score by eliminating total lymphocyte count from the items to adapt AML patients. In this cohort, both the NCCN 2017 risk group and sCONUT score successfully stratified the overall survival (OS) of the elderly patients. A multivariable analysis demonstrated that adverse group in NCCN 2017 and high sCONUT score were independently associated with poor 2-year OS. Both risk stratification based on NCCN 2017 and sCONUT score predict prognosis in the elderly patients with newly diagnosed AML. Nature Publishing Group UK 2020-11-10 /pmc/articles/PMC7655799/ /pubmed/33173122 http://dx.doi.org/10.1038/s41598-020-76250-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Senjo, Hajime
Onozawa, Masahiro
Hidaka, Daisuke
Yokoyama, Shota
Yamamoto, Satoshi
Tsutsumi, Yutaka
Haseyama, Yoshihito
Nagashima, Takahiro
Mori, Akio
Ota, Shuichi
Sakai, Hajime
Ishihara, Toshimichi
Miyagishima, Takuto
Kakinoki, Yasutaka
Kurosawa, Mitsutoshi
Kobayashi, Hajime
Iwasaki, Hiroshi
Hashimoto, Daigo
Kondo, Takeshi
Teshima, Takanori
A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia
title A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia
title_full A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia
title_fullStr A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia
title_full_unstemmed A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia
title_short A novel nutritional index “simplified CONUT” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia
title_sort novel nutritional index “simplified conut” and the disease risk index independently stratify prognosis of elderly patients with acute myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655799/
https://www.ncbi.nlm.nih.gov/pubmed/33173122
http://dx.doi.org/10.1038/s41598-020-76250-8
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