Cargando…
Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies
Repetitive transcranial magnetic stimulation (rTMS) has gained growing interest for the treatment of major depression (MDD) and treatment-resistant depression (TRD). Most knowledge on rTMS comes from human studies as preclinical application has been problematic. However, recent optimization of rTMS...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655822/ https://www.ncbi.nlm.nih.gov/pubmed/33173042 http://dx.doi.org/10.1038/s41398-020-01055-2 |
_version_ | 1783608249383124992 |
---|---|
author | De Risio, Luisa Borgi, Marta Pettorruso, Mauro Miuli, Andrea Ottomana, Angela Maria Sociali, Antonella Martinotti, Giovanni Nicolò, Giuseppe Macrì, Simone di Giannantonio, Massimo Zoratto, Francesca |
author_facet | De Risio, Luisa Borgi, Marta Pettorruso, Mauro Miuli, Andrea Ottomana, Angela Maria Sociali, Antonella Martinotti, Giovanni Nicolò, Giuseppe Macrì, Simone di Giannantonio, Massimo Zoratto, Francesca |
author_sort | De Risio, Luisa |
collection | PubMed |
description | Repetitive transcranial magnetic stimulation (rTMS) has gained growing interest for the treatment of major depression (MDD) and treatment-resistant depression (TRD). Most knowledge on rTMS comes from human studies as preclinical application has been problematic. However, recent optimization of rTMS in animal models has laid the foundations for improved translational studies. Preclinical studies have the potential to help identify optimal stimulation protocols and shed light on new neurobiological-based rationales for rTMS use. To assess existing evidence regarding rTMS effects on depressive-like symptoms in rodent models, we conducted a comprehensive literature search in accordance with PRISMA guidelines (PROSPERO registration number: CRD42019157549). In addition, we conducted a meta-analysis to determine rTMS efficacy, performing subgroup analyses to examine the impact of different experimental models and neuromodulation parameters. Assessment of the depressive-like phenotype was quite homogeneous whilst rTMS parameters among the 23 included studies varied considerably. Most studies used a stress-induced model. Overall, results show a largely beneficial effect of active rTMS compared to sham stimulation, as reflected in the statistically significant recovery of both helplessness (SDM 1.34 [1.02;1.66]) and anhedonic (SDM 1.87 [1.02;2.72]) profiles. Improvement of the depressive-like phenotype was obtained in all included models and independently of rTMS frequency. Nonetheless, these results have limited predictive value for TRD patients as only antidepressant-sensitive models were used. Extending rTMS studies to other MDD models, corresponding to distinct endophenotypes, and to TRD models is therefore crucial to test rTMS efficacy and to develop cost-effective protocols, with the potential of yielding faster clinical responses in MDD and TRD. |
format | Online Article Text |
id | pubmed-7655822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76558222020-11-12 Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies De Risio, Luisa Borgi, Marta Pettorruso, Mauro Miuli, Andrea Ottomana, Angela Maria Sociali, Antonella Martinotti, Giovanni Nicolò, Giuseppe Macrì, Simone di Giannantonio, Massimo Zoratto, Francesca Transl Psychiatry Review Article Repetitive transcranial magnetic stimulation (rTMS) has gained growing interest for the treatment of major depression (MDD) and treatment-resistant depression (TRD). Most knowledge on rTMS comes from human studies as preclinical application has been problematic. However, recent optimization of rTMS in animal models has laid the foundations for improved translational studies. Preclinical studies have the potential to help identify optimal stimulation protocols and shed light on new neurobiological-based rationales for rTMS use. To assess existing evidence regarding rTMS effects on depressive-like symptoms in rodent models, we conducted a comprehensive literature search in accordance with PRISMA guidelines (PROSPERO registration number: CRD42019157549). In addition, we conducted a meta-analysis to determine rTMS efficacy, performing subgroup analyses to examine the impact of different experimental models and neuromodulation parameters. Assessment of the depressive-like phenotype was quite homogeneous whilst rTMS parameters among the 23 included studies varied considerably. Most studies used a stress-induced model. Overall, results show a largely beneficial effect of active rTMS compared to sham stimulation, as reflected in the statistically significant recovery of both helplessness (SDM 1.34 [1.02;1.66]) and anhedonic (SDM 1.87 [1.02;2.72]) profiles. Improvement of the depressive-like phenotype was obtained in all included models and independently of rTMS frequency. Nonetheless, these results have limited predictive value for TRD patients as only antidepressant-sensitive models were used. Extending rTMS studies to other MDD models, corresponding to distinct endophenotypes, and to TRD models is therefore crucial to test rTMS efficacy and to develop cost-effective protocols, with the potential of yielding faster clinical responses in MDD and TRD. Nature Publishing Group UK 2020-11-10 /pmc/articles/PMC7655822/ /pubmed/33173042 http://dx.doi.org/10.1038/s41398-020-01055-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article De Risio, Luisa Borgi, Marta Pettorruso, Mauro Miuli, Andrea Ottomana, Angela Maria Sociali, Antonella Martinotti, Giovanni Nicolò, Giuseppe Macrì, Simone di Giannantonio, Massimo Zoratto, Francesca Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies |
title | Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies |
title_full | Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies |
title_fullStr | Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies |
title_full_unstemmed | Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies |
title_short | Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies |
title_sort | recovering from depression with repetitive transcranial magnetic stimulation (rtms): a systematic review and meta-analysis of preclinical studies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655822/ https://www.ncbi.nlm.nih.gov/pubmed/33173042 http://dx.doi.org/10.1038/s41398-020-01055-2 |
work_keys_str_mv | AT derisioluisa recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT borgimarta recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT pettorrusomauro recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT miuliandrea recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT ottomanaangelamaria recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT socialiantonella recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT martinottigiovanni recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT nicologiuseppe recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT macrisimone recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT digiannantoniomassimo recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies AT zorattofrancesca recoveringfromdepressionwithrepetitivetranscranialmagneticstimulationrtmsasystematicreviewandmetaanalysisofpreclinicalstudies |