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Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?

The human TP53 locus, located on the short arm of chromosome 17, encodes a tumour suppressor protein which functions as a tetrameric transcription factor capable of regulating the expression of a plethora of target genes involved in cell cycle arrest, apoptosis, DNA repair, autophagy, and metabolism...

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Detalles Bibliográficos
Autores principales:	Monti, Paola, Menichini, Paola, Speciale, Andrea, Cutrona, Giovanna, Fais, Franco, Taiana, Elisa, Neri, Antonino, Bomben, Riccardo, Gentile, Massimo, Gattei, Valter, Ferrarini, Manlio, Morabito, Fortunato, Fronza, Gilberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655923/ https://www.ncbi.nlm.nih.gov/pubmed/33194757 http://dx.doi.org/10.3389/fonc.2020.593383

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