Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics

Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated...

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Detalles Bibliográficos
Autores principales: Rajappa, Anuva, Banerjee, Sucharita, Sharma, Vivek, Khandelia, Piyush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655967/
https://www.ncbi.nlm.nih.gov/pubmed/33195421
http://dx.doi.org/10.3389/fmolb.2020.577938
Descripción
Sumario:Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer.

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