Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics

Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated...

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Autores principales: Rajappa, Anuva, Banerjee, Sucharita, Sharma, Vivek, Khandelia, Piyush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655967/
https://www.ncbi.nlm.nih.gov/pubmed/33195421
http://dx.doi.org/10.3389/fmolb.2020.577938
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author Rajappa, Anuva
Banerjee, Sucharita
Sharma, Vivek
Khandelia, Piyush
author_facet Rajappa, Anuva
Banerjee, Sucharita
Sharma, Vivek
Khandelia, Piyush
author_sort Rajappa, Anuva
collection PubMed
description Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer.
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spelling pubmed-76559672020-11-13 Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics Rajappa, Anuva Banerjee, Sucharita Sharma, Vivek Khandelia, Piyush Front Mol Biosci Molecular Biosciences Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence via a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer. Frontiers Media S.A. 2020-10-28 /pmc/articles/PMC7655967/ /pubmed/33195421 http://dx.doi.org/10.3389/fmolb.2020.577938 Text en Copyright © 2020 Rajappa, Banerjee, Sharma and Khandelia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Rajappa, Anuva
Banerjee, Sucharita
Sharma, Vivek
Khandelia, Piyush
Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics
title Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics
title_full Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics
title_fullStr Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics
title_full_unstemmed Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics
title_short Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics
title_sort circular rnas: emerging role in cancer diagnostics and therapeutics
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655967/
https://www.ncbi.nlm.nih.gov/pubmed/33195421
http://dx.doi.org/10.3389/fmolb.2020.577938
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