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TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with cognitive deficits and synaptic impairments. Amyloid-β (Aβ) plaque deposition, dystrophic neurite accumulation and neurofibrillary tangles are pathological hallmarks of AD. TMEM59 has been implicated to play a role i...

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Detalles Bibliográficos
Autores principales:	Meng, Jian, Han, Linkun, Zheng, Naizhen, Xu, Hui, Liu, Zhaoji, Zhang, Xian, Luo, Hong, Can, Dan, Sun, Hao, Xu, Huaxi, Zhang, Yun-wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655972/ https://www.ncbi.nlm.nih.gov/pubmed/33195275 http://dx.doi.org/10.3389/fcell.2020.596030

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