Impact of local treatment on survival from hematological malignancies causing spinal cord compression

BACKGROUND: Various hematological malignancies, including multiple myeloma, plasmacytoma, aggressive lymphoma, and indolent lymphoma, rarely result in spinal cord compression. METHODS: Here, we retrospectively analyzed 32 patients with multiple myeloma (50%), plasmacytoma (13%), aggressive lymphoma...

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Detalles Bibliográficos
Autores principales: Ghedira, Hela, Radhouane, Khaled, Mezni, Essia, Yahiaoui, Safia, Stambouli, Hela, Yedeas, Mohamed Dehmani, Belaid, Asma, Ammar, Chiraz, Kacem, Karima, Zriba, Samy, Msadek, Fehmi, Yedeas, Mondher, Harbaoui, Ahmed, Chkili, Ridha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656002/
https://www.ncbi.nlm.nih.gov/pubmed/33194285
http://dx.doi.org/10.25259/SNI_592_2020
Descripción
Sumario:BACKGROUND: Various hematological malignancies, including multiple myeloma, plasmacytoma, aggressive lymphoma, and indolent lymphoma, rarely result in spinal cord compression. METHODS: Here, we retrospectively analyzed 32 patients with multiple myeloma (50%), plasmacytoma (13%), aggressive lymphoma (28%), and indolent lymphoma (9%), resulting in spinal cord compression (2004 and 2016). Patients averaged 57 years of age and presented with the indolent onset of spinal cord compression (91% of cases) resulting mostly in motor deficits (69%). RESULTS: Local treatment modalities included radiotherapy (RT) (28%) alone, decompressive surgery (28%) alone, or decompressive surgery with consolidation RT (40%). The 1-year overall survival was 70%, and the progression-free survival frequency was 62%. CONCLUSION: This study highlighted the importance of standardizing the indications for RT alone versus RT with surgery depending on the patient’s underlying pathological diagnosis, neurological deficits, and radiological findings.

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