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Brain amyloid and the transition to dementia in Down syndrome

INTRODUCTION: Down syndrome (DS) is associated with elevated risk for Alzheimer's disease (AD) due to amyloid beta (Aβ) lifelong accumulation. We hypothesized that the spatial distribution of brain Aβ predicts future dementia conversion in individuals with DS. METHODS: We acquired (18)F‐florbet...

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Autores principales: Keator, David B., Doran, Eric, Taylor, Lisa, Phelan, Michael J., Hom, Christy, Tseung, Katherine, van Erp, Theo G. M., Potkin, Steven G., Brickman, Adam M., Rosas, Diana H., Yassa, Michael A., Silverman, Wayne, Lott, Ira T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656170/
https://www.ncbi.nlm.nih.gov/pubmed/33204814
http://dx.doi.org/10.1002/dad2.12126
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author Keator, David B.
Doran, Eric
Taylor, Lisa
Phelan, Michael J.
Hom, Christy
Tseung, Katherine
van Erp, Theo G. M.
Potkin, Steven G.
Brickman, Adam M.
Rosas, Diana H.
Yassa, Michael A.
Silverman, Wayne
Lott, Ira T.
author_facet Keator, David B.
Doran, Eric
Taylor, Lisa
Phelan, Michael J.
Hom, Christy
Tseung, Katherine
van Erp, Theo G. M.
Potkin, Steven G.
Brickman, Adam M.
Rosas, Diana H.
Yassa, Michael A.
Silverman, Wayne
Lott, Ira T.
author_sort Keator, David B.
collection PubMed
description INTRODUCTION: Down syndrome (DS) is associated with elevated risk for Alzheimer's disease (AD) due to amyloid beta (Aβ) lifelong accumulation. We hypothesized that the spatial distribution of brain Aβ predicts future dementia conversion in individuals with DS. METHODS: We acquired (18)F‐florbetapir positron emission tomography scans from 19 nondemented individuals with DS at baseline and monitored them for 4 years, with five individuals transitioning to dementia. Machine learning classification using an independent test set determined features on (18)F‐florbetapir standardized uptake value ratio maps that predicted transition. RESULTS: In addition to “AD signature” regions including the inferior parietal cortex, temporal lobes, and the cingulum, we found that Aβ cortical binding in the prefrontal and superior frontal cortices distinguished subjects who transitioned to dementia. Classification did well in predicting transitioners. DISCUSSION: Our study suggests that specific regional profiles of brain amyloid in older adults with DS may predict cognitive decline and are informative in evaluating the risk for dementia.
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spelling pubmed-76561702020-11-16 Brain amyloid and the transition to dementia in Down syndrome Keator, David B. Doran, Eric Taylor, Lisa Phelan, Michael J. Hom, Christy Tseung, Katherine van Erp, Theo G. M. Potkin, Steven G. Brickman, Adam M. Rosas, Diana H. Yassa, Michael A. Silverman, Wayne Lott, Ira T. Alzheimers Dement (Amst) Article INTRODUCTION: Down syndrome (DS) is associated with elevated risk for Alzheimer's disease (AD) due to amyloid beta (Aβ) lifelong accumulation. We hypothesized that the spatial distribution of brain Aβ predicts future dementia conversion in individuals with DS. METHODS: We acquired (18)F‐florbetapir positron emission tomography scans from 19 nondemented individuals with DS at baseline and monitored them for 4 years, with five individuals transitioning to dementia. Machine learning classification using an independent test set determined features on (18)F‐florbetapir standardized uptake value ratio maps that predicted transition. RESULTS: In addition to “AD signature” regions including the inferior parietal cortex, temporal lobes, and the cingulum, we found that Aβ cortical binding in the prefrontal and superior frontal cortices distinguished subjects who transitioned to dementia. Classification did well in predicting transitioners. DISCUSSION: Our study suggests that specific regional profiles of brain amyloid in older adults with DS may predict cognitive decline and are informative in evaluating the risk for dementia. John Wiley and Sons Inc. 2020-11-11 /pmc/articles/PMC7656170/ /pubmed/33204814 http://dx.doi.org/10.1002/dad2.12126 Text en © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Article
Keator, David B.
Doran, Eric
Taylor, Lisa
Phelan, Michael J.
Hom, Christy
Tseung, Katherine
van Erp, Theo G. M.
Potkin, Steven G.
Brickman, Adam M.
Rosas, Diana H.
Yassa, Michael A.
Silverman, Wayne
Lott, Ira T.
Brain amyloid and the transition to dementia in Down syndrome
title Brain amyloid and the transition to dementia in Down syndrome
title_full Brain amyloid and the transition to dementia in Down syndrome
title_fullStr Brain amyloid and the transition to dementia in Down syndrome
title_full_unstemmed Brain amyloid and the transition to dementia in Down syndrome
title_short Brain amyloid and the transition to dementia in Down syndrome
title_sort brain amyloid and the transition to dementia in down syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656170/
https://www.ncbi.nlm.nih.gov/pubmed/33204814
http://dx.doi.org/10.1002/dad2.12126
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