Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19

The spread of pathogenic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a global health emergency. Based on the symptomatic treatment and supporting therapy, prevention of complications is the major treatment option. Therefore, it is necessary to illustrate the potential mechanis...

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Autores principales: Lu, Ling, Liu, Xiaomei, Jin, Rong, Guan, Renzheng, Lin, Rongjun, Qu, Zhenghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656237/
https://www.ncbi.nlm.nih.gov/pubmed/33204713
http://dx.doi.org/10.1155/2020/7520746
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author Lu, Ling
Liu, Xiaomei
Jin, Rong
Guan, Renzheng
Lin, Rongjun
Qu, Zhenghai
author_facet Lu, Ling
Liu, Xiaomei
Jin, Rong
Guan, Renzheng
Lin, Rongjun
Qu, Zhenghai
author_sort Lu, Ling
collection PubMed
description The spread of pathogenic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a global health emergency. Based on the symptomatic treatment and supporting therapy, prevention of complications is the major treatment option. Therefore, it is necessary to illustrate the potential mechanisms for the pathogenesis of COVID-19. Angiotensin-converting enzyme 2 (ACE2), the major receptor of SARS-CoV-2, is one of the major members of the renin-angiotensin system (RAS). In this review, we aimed to summarize the crucial roles of ACE2 in the pathogenesis of COVID-19, followed by illustrating potential treatment options relating to ACE2 and the RAS.
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spelling pubmed-76562372020-11-16 Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19 Lu, Ling Liu, Xiaomei Jin, Rong Guan, Renzheng Lin, Rongjun Qu, Zhenghai Biomed Res Int Research Article The spread of pathogenic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a global health emergency. Based on the symptomatic treatment and supporting therapy, prevention of complications is the major treatment option. Therefore, it is necessary to illustrate the potential mechanisms for the pathogenesis of COVID-19. Angiotensin-converting enzyme 2 (ACE2), the major receptor of SARS-CoV-2, is one of the major members of the renin-angiotensin system (RAS). In this review, we aimed to summarize the crucial roles of ACE2 in the pathogenesis of COVID-19, followed by illustrating potential treatment options relating to ACE2 and the RAS. Hindawi 2020-11-05 /pmc/articles/PMC7656237/ /pubmed/33204713 http://dx.doi.org/10.1155/2020/7520746 Text en Copyright © 2020 Ling Lu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lu, Ling
Liu, Xiaomei
Jin, Rong
Guan, Renzheng
Lin, Rongjun
Qu, Zhenghai
Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19
title Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19
title_full Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19
title_fullStr Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19
title_full_unstemmed Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19
title_short Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19
title_sort potential roles of the renin-angiotensin system in the pathogenesis and treatment of covid-19
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656237/
https://www.ncbi.nlm.nih.gov/pubmed/33204713
http://dx.doi.org/10.1155/2020/7520746
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