Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity

Mutations in the PARK2 gene encoding the protein parkin cause autosomal recessive juvenile Parkinsonism (ARJP), a neurodegenerative disease characterized by dysfunction and death of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Since a neuroprotective therapy for ARJP does not e...

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Detalles Bibliográficos
Autores principales: Regoni, Maria, Cattaneo, Stefano, Mercatelli, Daniela, Novello, Salvatore, Passoni, Alice, Bagnati, Renzo, Davoli, Enrico, Croci, Laura, Consalez, Gian Giacomo, Albanese, Federica, Zanetti, Letizia, Passafaro, Maria, Serratto, Giulia Maia, Di Fonzo, Alessio, Valtorta, Flavia, Ciammola, Andrea, Taverna, Stefano, Morari, Michele, Sassone, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656261/
https://www.ncbi.nlm.nih.gov/pubmed/33173027
http://dx.doi.org/10.1038/s41419-020-03172-8

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