Mir142 loss unlocks IDH2(R140)-dependent leukemogenesis through antagonistic regulation of HOX genes

AML is a genetically heterogeneous disease and understanding how different co-occurring mutations cooperate to drive leukemogenesis will be crucial for improving diagnostic and therapeutic options for patients. MIR142 mutations have been recurrently detected in IDH-mutated AML samples. Here, we have...

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Detalles Bibliográficos
Autores principales: Marshall, A., Kasturiarachchi, J., Datta, P., Guo, Y., Deltcheva, E., James, C., Brown, J., May, G., Anandagoda, N., Jackson, I., Howard, J. K., Ghazaly, E., Brooks, S., Khwaja, A., Araki, M., Araki, K., Linch, D., Lord, G. M., Enver, T., Nimmo, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656267/
https://www.ncbi.nlm.nih.gov/pubmed/33173219
http://dx.doi.org/10.1038/s41598-020-76218-8

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