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Paraneoplastic syndromes in small cell lung cancer
Paraneoplastic syndromes can commonly occur due to lung cancer, especially small cell lung cancer. Frequently paraneoplastic syndromes can precede the diagnosis of the neoplasm or present with limited stage disease. However, these syndromes can also occur at the time of recurrence or metastasis of d...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656388/ https://www.ncbi.nlm.nih.gov/pubmed/33209464 http://dx.doi.org/10.21037/jtd.2020.03.88 |
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author | Soomro, Zaid Youssef, Michael Yust-Katz, Shlomit Jalali, Ali Patel, Akash J. Mandel, Jacob |
author_facet | Soomro, Zaid Youssef, Michael Yust-Katz, Shlomit Jalali, Ali Patel, Akash J. Mandel, Jacob |
author_sort | Soomro, Zaid |
collection | PubMed |
description | Paraneoplastic syndromes can commonly occur due to lung cancer, especially small cell lung cancer. Frequently paraneoplastic syndromes can precede the diagnosis of the neoplasm or present with limited stage disease. However, these syndromes can also occur at the time of recurrence or metastasis of disease. This review focuses on the epidemiology, pathogenesis, clinical features, and current management of the most common paraneoplastic syndromes encountered in patients with small cell lung cancer. Manifestations of paraneoplastic syndromes in small cell lung cancer include endocrine syndromes with secretion of excess hormones, and neurologic syndromes due to the production of antibodies causing an autoimmune condition. Recent advances have allowed for greater understanding of these syndromes and for the development of improved diagnostic as well as therapeutic tools. Awareness of paraneoplastic syndromes in small cell lung cancer can lead to an earlier diagnosis and recognition of both the condition and in some cases the disease potentially improving the overall survival and prognosis for patients. Further research examining effective methods to improve recovery from neurologic deficits in patients with a paraneoplastic neurologic illness is warranted. |
format | Online Article Text |
id | pubmed-7656388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-76563882020-11-17 Paraneoplastic syndromes in small cell lung cancer Soomro, Zaid Youssef, Michael Yust-Katz, Shlomit Jalali, Ali Patel, Akash J. Mandel, Jacob J Thorac Dis Review Article on Small Cell Lung Cancer Paraneoplastic syndromes can commonly occur due to lung cancer, especially small cell lung cancer. Frequently paraneoplastic syndromes can precede the diagnosis of the neoplasm or present with limited stage disease. However, these syndromes can also occur at the time of recurrence or metastasis of disease. This review focuses on the epidemiology, pathogenesis, clinical features, and current management of the most common paraneoplastic syndromes encountered in patients with small cell lung cancer. Manifestations of paraneoplastic syndromes in small cell lung cancer include endocrine syndromes with secretion of excess hormones, and neurologic syndromes due to the production of antibodies causing an autoimmune condition. Recent advances have allowed for greater understanding of these syndromes and for the development of improved diagnostic as well as therapeutic tools. Awareness of paraneoplastic syndromes in small cell lung cancer can lead to an earlier diagnosis and recognition of both the condition and in some cases the disease potentially improving the overall survival and prognosis for patients. Further research examining effective methods to improve recovery from neurologic deficits in patients with a paraneoplastic neurologic illness is warranted. AME Publishing Company 2020-10 /pmc/articles/PMC7656388/ /pubmed/33209464 http://dx.doi.org/10.21037/jtd.2020.03.88 Text en 2020 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article on Small Cell Lung Cancer Soomro, Zaid Youssef, Michael Yust-Katz, Shlomit Jalali, Ali Patel, Akash J. Mandel, Jacob Paraneoplastic syndromes in small cell lung cancer |
title | Paraneoplastic syndromes in small cell lung cancer |
title_full | Paraneoplastic syndromes in small cell lung cancer |
title_fullStr | Paraneoplastic syndromes in small cell lung cancer |
title_full_unstemmed | Paraneoplastic syndromes in small cell lung cancer |
title_short | Paraneoplastic syndromes in small cell lung cancer |
title_sort | paraneoplastic syndromes in small cell lung cancer |
topic | Review Article on Small Cell Lung Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656388/ https://www.ncbi.nlm.nih.gov/pubmed/33209464 http://dx.doi.org/10.21037/jtd.2020.03.88 |
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