Cargando…

Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection

Detalles Bibliográficos
Autores principales:	Guo, Liang, Bi, Wenwen, Wang, Xinling, Xu, Wei, Yan, Renhong, Zhang, Yuanyuan, Zhao, Kai, Li, Yaning, Zhang, Mingfeng, Cai, Xia, Jiang, Shibo, Xie, Youhua, Zhou, Qiang, Lu, Lu, Dang, Bobo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2020
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656503/ https://www.ncbi.nlm.nih.gov/pubmed/33177651 http://dx.doi.org/10.1038/s41422-020-00438-w

Ejemplares similares

Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo
por: Li, Mengjiao, et al.
Publicado: (2022)

Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2
por: Yan, Renhong, et al.
Publicado: (2021)

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
por: Xu, Cong, et al.
Publicado: (2021)

Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody
por: Yin, Wanchao, et al.
Publicado: (2022)

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
por: Schoof, Michael, et al.
Publicado: (2020)

Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 receptor
por: Li, Yaning, et al.
Publicado: (2023)

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
por: Yan, Renhong, et al.
Publicado: (2020)

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
por: Chen, Yuning, et al.
Publicado: (2021)

Multiple conformations of trimeric spikes visualized on a non-enveloped virus
por: Zhang, Yinong, et al.
Publicado: (2022)

ACE2, B(0)AT1, and SARS-CoV-2 spike protein: Structural and functional implications
por: Zhang, Yuanyuan, et al.
Publicado: (2022)

Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants
por: Bi, Wenwen, et al.
Publicado: (2022)

Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2
por: Shen, Yaping, et al.
Publicado: (2022)

Retraction Note to: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
por: Wang, Xinling, et al.
Publicado: (2020)

RETRACTED ARTICLE: SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion
por: Wang, Xinling, et al.
Publicado: (2020)

Structural insight into the substrate recognition and transport mechanism of amino acid transporter complex ACE2-B(0)AT1 and ACE2-SIT1
por: Li, Yaning, et al.
Publicado: (2023)

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
por: McCallum, Matthew, et al.
Publicado: (2020)

The SARS-CoV-2 spike protein reversibly samples an open-trimer conformation exposing novel epitopes
por: Shoemaker, Sophie R., et al.
Publicado: (2022)

Trimeric receptor-binding domain of SARS-CoV-2 acts as a potent inhibitor of ACE2 receptor-mediated viral entry
por: Basavarajappa, Shrikanth C., et al.
Publicado: (2022)

Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations
por: Sakkiah, Sugunadevi, et al.
Publicado: (2021)

Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer
por: Guerrini, Giuditta, et al.
Publicado: (2023)

A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding
por: Wang, Yingdan, et al.
Publicado: (2022)

Stabilizing the closed SARS-CoV-2 spike trimer
por: Juraszek, Jarek, et al.
Publicado: (2021)

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
por: Luan, Junwen, et al.
Publicado: (2020)

Distinct Conformations of SARS-CoV-2 Omicron Spike Protein and Its Interaction with ACE2 and Antibody
por: Lee, Myeongsang, et al.
Publicado: (2023)

Intricacies of the SARS-CoV-2 spike transmembrane trimer organization
por: Aliper, Elena T., et al.
Publicado: (2022)

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response
por: Liu, Zezhong, et al.
Publicado: (2020)

Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM
por: Wang, Yifan, et al.
Publicado: (2021)

In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer
por: Bharathi, Muruganantham, et al.
Publicado: (2022)

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk and enhanced NTD dynamics
por: Anand, Ganesh S., et al.
Publicado: (2023)

Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics
por: Braet, Sean M, et al.
Publicado: (2023)

Potent Neutralization Antibodies Induced by a Recombinant Trimeric Spike Protein Vaccine Candidate Containing PIKA Adjuvant for COVID-19
por: Tong, Jiao, et al.
Publicado: (2021)

SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
por: Wang, Xinling, et al.
Publicado: (2023)

Mass photometry reveals SARS-CoV-2 spike stabilisation to impede ACE2 binding through altered conformational dynamics
por: Burnap, Sean A., et al.
Publicado: (2022)

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction
por: Guimond, Scott E., et al.
Publicado: (2022)

Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates
por: Stuible, Matthew, et al.
Publicado: (2023)

Spike residue 403 affects binding of coronavirus spikes to human ACE2
por: Zech, Fabian, et al.
Publicado: (2021)

Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants
por: Li, Yaning, et al.
Publicado: (2022)

A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses
por: Cai, Yanxing, et al.
Publicado: (2021)

Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants
por: Ou, Junxian, et al.
Publicado: (2022)

Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking
por: Liu, Lihong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8othouh47au03fu588mdkhkejb