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Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study

OBJECTIVES: To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital. DESIGN AND SETTING: Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor...

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Autores principales: Jiménez, Eva, Fontán-Vela, Mario, Valencia, Jorge, Fernandez-Jimenez, Ines, Álvaro-Alonso, Elena Alba, Izquierdo-García, Elsa, Lazaro Cebas, Andrea, Gallego Ruiz-Elvira, Elisa, Troya, Jesús, Tebar-Martinez, Ana Josefa, Garcia-Marina, Belén, Peña-Lillo, Gabriela, Abad-Motos, Ane, Macaya, Laura, Ryan, Pablo, Pérez-Butragueño, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656887/
https://www.ncbi.nlm.nih.gov/pubmed/33172949
http://dx.doi.org/10.1136/bmjopen-2020-042398
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author Jiménez, Eva
Fontán-Vela, Mario
Valencia, Jorge
Fernandez-Jimenez, Ines
Álvaro-Alonso, Elena Alba
Izquierdo-García, Elsa
Lazaro Cebas, Andrea
Gallego Ruiz-Elvira, Elisa
Troya, Jesús
Tebar-Martinez, Ana Josefa
Garcia-Marina, Belén
Peña-Lillo, Gabriela
Abad-Motos, Ane
Macaya, Laura
Ryan, Pablo
Pérez-Butragueño, Mario
author_facet Jiménez, Eva
Fontán-Vela, Mario
Valencia, Jorge
Fernandez-Jimenez, Ines
Álvaro-Alonso, Elena Alba
Izquierdo-García, Elsa
Lazaro Cebas, Andrea
Gallego Ruiz-Elvira, Elisa
Troya, Jesús
Tebar-Martinez, Ana Josefa
Garcia-Marina, Belén
Peña-Lillo, Gabriela
Abad-Motos, Ane
Macaya, Laura
Ryan, Pablo
Pérez-Butragueño, Mario
author_sort Jiménez, Eva
collection PubMed
description OBJECTIVES: To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital. DESIGN AND SETTING: Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain. PARTICIPANTS: All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020. RESULTS: A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0–81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51–71); 74.1% men; median length of stay 9 days (IQR 5–19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6–14). CONCLUSIONS: This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity.
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spelling pubmed-76568872020-11-12 Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study Jiménez, Eva Fontán-Vela, Mario Valencia, Jorge Fernandez-Jimenez, Ines Álvaro-Alonso, Elena Alba Izquierdo-García, Elsa Lazaro Cebas, Andrea Gallego Ruiz-Elvira, Elisa Troya, Jesús Tebar-Martinez, Ana Josefa Garcia-Marina, Belén Peña-Lillo, Gabriela Abad-Motos, Ane Macaya, Laura Ryan, Pablo Pérez-Butragueño, Mario BMJ Open Epidemiology OBJECTIVES: To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital. DESIGN AND SETTING: Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain. PARTICIPANTS: All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020. RESULTS: A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0–81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51–71); 74.1% men; median length of stay 9 days (IQR 5–19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6–14). CONCLUSIONS: This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity. BMJ Publishing Group 2020-11-10 /pmc/articles/PMC7656887/ /pubmed/33172949 http://dx.doi.org/10.1136/bmjopen-2020-042398 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Jiménez, Eva
Fontán-Vela, Mario
Valencia, Jorge
Fernandez-Jimenez, Ines
Álvaro-Alonso, Elena Alba
Izquierdo-García, Elsa
Lazaro Cebas, Andrea
Gallego Ruiz-Elvira, Elisa
Troya, Jesús
Tebar-Martinez, Ana Josefa
Garcia-Marina, Belén
Peña-Lillo, Gabriela
Abad-Motos, Ane
Macaya, Laura
Ryan, Pablo
Pérez-Butragueño, Mario
Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study
title Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study
title_full Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study
title_fullStr Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study
title_full_unstemmed Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study
title_short Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study
title_sort characteristics, complications and outcomes among 1549 patients hospitalised with covid-19 in a secondary hospital in madrid, spain: a retrospective case series study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7656887/
https://www.ncbi.nlm.nih.gov/pubmed/33172949
http://dx.doi.org/10.1136/bmjopen-2020-042398
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