Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy

• Vitamin D has antiinflammatory and immunoregulatory functions. • The involvement of vitamin D in the pathophysiology of coronavirus disease 2019 (COVID-19) is still not clear. • Some studies support a link between vitamin D deficiency and worse COVID-19 outcomes. • Vitamin D may also enhance macro...

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Detalles Bibliográficos
Autores principales: Cereda, Emanuele, Bogliolo, Laura, Lobascio, Federica, Barichella, Michela, Zecchinelli, Anna Lena, Pezzoli, Gianni, Caccialanza, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Applied Nutritional Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657015/
https://www.ncbi.nlm.nih.gov/pubmed/33288411
http://dx.doi.org/10.1016/j.nut.2020.111055
Descripción
Sumario:• Vitamin D has antiinflammatory and immunoregulatory functions. • The involvement of vitamin D in the pathophysiology of coronavirus disease 2019 (COVID-19) is still not clear. • Some studies support a link between vitamin D deficiency and worse COVID-19 outcomes. • Vitamin D may also enhance macrophage activation and aberrant immune response. • In our study, vitamin D supplementation was associated with a trend toward higher mortality. • Supplementation trials are crucial to clarify the role of vitamin D in COVID-19.

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