Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy

• Vitamin D has antiinflammatory and immunoregulatory functions. • The involvement of vitamin D in the pathophysiology of coronavirus disease 2019 (COVID-19) is still not clear. • Some studies support a link between vitamin D deficiency and worse COVID-19 outcomes. • Vitamin D may also enhance macro...

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Autores principales: Cereda, Emanuele, Bogliolo, Laura, Lobascio, Federica, Barichella, Michela, Zecchinelli, Anna Lena, Pezzoli, Gianni, Caccialanza, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Applied Nutritional Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657015/
https://www.ncbi.nlm.nih.gov/pubmed/33288411
http://dx.doi.org/10.1016/j.nut.2020.111055
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author Cereda, Emanuele
Bogliolo, Laura
Lobascio, Federica
Barichella, Michela
Zecchinelli, Anna Lena
Pezzoli, Gianni
Caccialanza, Riccardo
author_facet Cereda, Emanuele
Bogliolo, Laura
Lobascio, Federica
Barichella, Michela
Zecchinelli, Anna Lena
Pezzoli, Gianni
Caccialanza, Riccardo
author_sort Cereda, Emanuele
collection PubMed
description • Vitamin D has antiinflammatory and immunoregulatory functions. • The involvement of vitamin D in the pathophysiology of coronavirus disease 2019 (COVID-19) is still not clear. • Some studies support a link between vitamin D deficiency and worse COVID-19 outcomes. • Vitamin D may also enhance macrophage activation and aberrant immune response. • In our study, vitamin D supplementation was associated with a trend toward higher mortality. • Supplementation trials are crucial to clarify the role of vitamin D in COVID-19.
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spelling pubmed-76570152020-11-12 Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy Cereda, Emanuele Bogliolo, Laura Lobascio, Federica Barichella, Michela Zecchinelli, Anna Lena Pezzoli, Gianni Caccialanza, Riccardo Nutrition Applied Nutritional Investigation • Vitamin D has antiinflammatory and immunoregulatory functions. • The involvement of vitamin D in the pathophysiology of coronavirus disease 2019 (COVID-19) is still not clear. • Some studies support a link between vitamin D deficiency and worse COVID-19 outcomes. • Vitamin D may also enhance macrophage activation and aberrant immune response. • In our study, vitamin D supplementation was associated with a trend toward higher mortality. • Supplementation trials are crucial to clarify the role of vitamin D in COVID-19. Elsevier Inc. 2021-02 2020-11-11 /pmc/articles/PMC7657015/ /pubmed/33288411 http://dx.doi.org/10.1016/j.nut.2020.111055 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Applied Nutritional Investigation
Cereda, Emanuele
Bogliolo, Laura
Lobascio, Federica
Barichella, Michela
Zecchinelli, Anna Lena
Pezzoli, Gianni
Caccialanza, Riccardo
Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy
title Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy
title_full Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy
title_fullStr Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy
title_full_unstemmed Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy
title_short Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy
title_sort vitamin d supplementation and outcomes in coronavirus disease 2019 (covid-19) patients from the outbreak area of lombardy, italy
topic Applied Nutritional Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657015/
https://www.ncbi.nlm.nih.gov/pubmed/33288411
http://dx.doi.org/10.1016/j.nut.2020.111055
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