COVID19- clinical presentation and therapeutic considerations

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the main drivers of more severe disease. Despite sign...

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Detalles Bibliográficos
Autores principales: Kenny, Grace, Mallon, Patrick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657079/
https://www.ncbi.nlm.nih.gov/pubmed/33218685
http://dx.doi.org/10.1016/j.bbrc.2020.11.021
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author Kenny, Grace
Mallon, Patrick W.
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Mallon, Patrick W.
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description The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the main drivers of more severe disease. Despite significant research endeavours, very few effective therapies have been identified, in part related to the different pathogenic mechanisms underlying different stages of clinical COVID-19. This mini review summarises data related to current and potential future therapies for COVID-19 and highlights the many challenges inherent in developing effective therapeutic options for new pandemic infection.
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spelling pubmed-76570792020-11-12 COVID19- clinical presentation and therapeutic considerations Kenny, Grace Mallon, Patrick W. Biochem Biophys Res Commun Article The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a pandemic infection in 2020 has presented many therapeutic challenges. Not least among these is the importance of abnormal host response to infection that is one of the main drivers of more severe disease. Despite significant research endeavours, very few effective therapies have been identified, in part related to the different pathogenic mechanisms underlying different stages of clinical COVID-19. This mini review summarises data related to current and potential future therapies for COVID-19 and highlights the many challenges inherent in developing effective therapeutic options for new pandemic infection. The Authors. Published by Elsevier Inc. 2021-01-29 2020-11-11 /pmc/articles/PMC7657079/ /pubmed/33218685 http://dx.doi.org/10.1016/j.bbrc.2020.11.021 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kenny, Grace
Mallon, Patrick W.
COVID19- clinical presentation and therapeutic considerations
title COVID19- clinical presentation and therapeutic considerations
title_full COVID19- clinical presentation and therapeutic considerations
title_fullStr COVID19- clinical presentation and therapeutic considerations
title_full_unstemmed COVID19- clinical presentation and therapeutic considerations
title_short COVID19- clinical presentation and therapeutic considerations
title_sort covid19- clinical presentation and therapeutic considerations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657079/
https://www.ncbi.nlm.nih.gov/pubmed/33218685
http://dx.doi.org/10.1016/j.bbrc.2020.11.021
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