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Spinal Tuberculosis Treatment: An Enduring Bone of Contention
Spinal tuberculosis is the most common form of extrapulmonary tuberculosis. It is of great importance to neurologists because of the potentially devastating complication of paraplegia, which may set in during active disease or the healed phase. Due to the deep-seated nature of the disease, definitiv...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657285/ https://www.ncbi.nlm.nih.gov/pubmed/33223659 http://dx.doi.org/10.4103/aian.AIAN_141_20 |
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author | Garg, Divyani Goyal, Vinay |
author_facet | Garg, Divyani Goyal, Vinay |
author_sort | Garg, Divyani |
collection | PubMed |
description | Spinal tuberculosis is the most common form of extrapulmonary tuberculosis. It is of great importance to neurologists because of the potentially devastating complication of paraplegia, which may set in during active disease or the healed phase. Due to the deep-seated nature of the disease, definitive diagnosis is often challenging. There is no clear consensus on the appropriate duration of therapy for spinal tuberculosis, with various guidelines recommending treatment from as short as 6 months to up to 18 months. In this article, we present a critical appraisal of the evidence on the same. In our opinion, the duration of antitubercular therapy needs to be individualized and the decision to terminate therapy should be multifactorial (clinical, radiological, pathological/microbiological where possible) rather than being enmeshed within any particular guideline. |
format | Online Article Text |
id | pubmed-7657285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-76572852020-11-19 Spinal Tuberculosis Treatment: An Enduring Bone of Contention Garg, Divyani Goyal, Vinay Ann Indian Acad Neurol AIAN Review Spinal tuberculosis is the most common form of extrapulmonary tuberculosis. It is of great importance to neurologists because of the potentially devastating complication of paraplegia, which may set in during active disease or the healed phase. Due to the deep-seated nature of the disease, definitive diagnosis is often challenging. There is no clear consensus on the appropriate duration of therapy for spinal tuberculosis, with various guidelines recommending treatment from as short as 6 months to up to 18 months. In this article, we present a critical appraisal of the evidence on the same. In our opinion, the duration of antitubercular therapy needs to be individualized and the decision to terminate therapy should be multifactorial (clinical, radiological, pathological/microbiological where possible) rather than being enmeshed within any particular guideline. Wolters Kluwer - Medknow 2020 2020-07-16 /pmc/articles/PMC7657285/ /pubmed/33223659 http://dx.doi.org/10.4103/aian.AIAN_141_20 Text en Copyright: © 2006 - 2020 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | AIAN Review Garg, Divyani Goyal, Vinay Spinal Tuberculosis Treatment: An Enduring Bone of Contention |
title | Spinal Tuberculosis Treatment: An Enduring Bone of Contention |
title_full | Spinal Tuberculosis Treatment: An Enduring Bone of Contention |
title_fullStr | Spinal Tuberculosis Treatment: An Enduring Bone of Contention |
title_full_unstemmed | Spinal Tuberculosis Treatment: An Enduring Bone of Contention |
title_short | Spinal Tuberculosis Treatment: An Enduring Bone of Contention |
title_sort | spinal tuberculosis treatment: an enduring bone of contention |
topic | AIAN Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657285/ https://www.ncbi.nlm.nih.gov/pubmed/33223659 http://dx.doi.org/10.4103/aian.AIAN_141_20 |
work_keys_str_mv | AT gargdivyani spinaltuberculosistreatmentanenduringboneofcontention AT goyalvinay spinaltuberculosistreatmentanenduringboneofcontention |