A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance

BACKGROUND: Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MeCP2) gene. While MeCP2 mutations are lethal in most males, females survive birth but show severe neurological defects. Because X-chromosome inactivation (XCI) is a ran...

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Detalles Bibliográficos
Autores principales: Lee, Hyeong-Min, Kuijer, M. Bram, Ruiz Blanes, Nerea, Clark, Ellen P., Aita, Megumi, Galiano Arjona, Lorena, Kokot, Agnieszka, Sciaky, Noah, Simon, Jeremy M., Bhatnagar, Sanchita, Philpot, Benjamin D., Cerase, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657357/
https://www.ncbi.nlm.nih.gov/pubmed/33172406
http://dx.doi.org/10.1186/s11689-020-09332-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657357/
https://www.ncbi.nlm.nih.gov/pubmed/33172406
http://dx.doi.org/10.1186/s11689-020-09332-3

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