Cargando…
A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance
BACKGROUND: Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MeCP2) gene. While MeCP2 mutations are lethal in most males, females survive birth but show severe neurological defects. Because X-chromosome inactivation (XCI) is a ran...
Autores principales: | Lee, Hyeong-Min, Kuijer, M. Bram, Ruiz Blanes, Nerea, Clark, Ellen P., Aita, Megumi, Galiano Arjona, Lorena, Kokot, Agnieszka, Sciaky, Noah, Simon, Jeremy M., Bhatnagar, Sanchita, Philpot, Benjamin D., Cerase, Andrea |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657357/ https://www.ncbi.nlm.nih.gov/pubmed/33172406 http://dx.doi.org/10.1186/s11689-020-09332-3 |
Ejemplares similares
-
MeCP2 and Chromatin Compartmentalization
por: Schmidt, Annika, et al.
Publicado: (2020) -
The role of MeCP2 in learning and memory
por: Robinson, Holly A., et al.
Publicado: (2019) -
Rett Syndrome and MECP2 Duplication Syndrome: Disorders of MeCP2 Dosage
por: Collins, Bridget E, et al.
Publicado: (2022) -
Genetic Modifiers of MeCP2 Function in Drosophila
por: Cukier, Holly N., et al.
Publicado: (2008) -
MeCP2-Related Diseases and Animal Models
por: Ezeonwuka, Chinelo D., et al.
Publicado: (2014)