Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

Astrocyte dysfunction is a primary factor in hepatic encephalopathy (HE) impairing neuronal activity under hyperammonemia. In particular, the early events causing ammonia-induced toxicity to astrocytes are not well understood. Using established cellular HE models, we show that mitochondria rapidly u...

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Detalles Bibliográficos
Autores principales: Drews, Leonie, Zimmermann, Marcel, Westhoff, Philipp, Brilhaus, Dominik, Poss, Rebecca E., Bergmann, Laura, Wiek, Constanze, Brenneisen, Peter, Piekorz, Roland P., Mettler-Altmann, Tabea, Weber, Andreas P. M., Reichert, Andreas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657470/
https://www.ncbi.nlm.nih.gov/pubmed/32917661
http://dx.doi.org/10.1242/dmm.047134

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