Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants

OBJECTIVE: The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo data is available on undisturbed gastrointestinal mo...

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Detalles Bibliográficos
Autores principales: Heissam, Khaled, Abrehart, Nichola, Hoad, Caroline L., Wright, Jeff, Menys, Alex, Murray, Kathryn, Glover, Paul M., Hebbard, Geoffrey, Gowland, Penny A., Baker, Jason, Hasler, William L., Spiller, Robin C., Corsetti, Maura, Brasseur, James G., Hens, Bart, Shedden, Kerby, Dickens, Joseph, Mudie, Deanna M., Amidon, Greg E., Amidon, Gordon L., Marciani, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657519/
https://www.ncbi.nlm.nih.gov/pubmed/33175860
http://dx.doi.org/10.1371/journal.pone.0241441

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