Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients

Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not receiving ivermectin. No differences were found b...

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Autores principales: Camprubí, Daniel, Almuedo-Riera, Alex, Martí-Soler, Helena, Soriano, Alex, Hurtado, Juan Carlos, Subirà, Carme, Grau-Pujol, Berta, Krolewiecki, Alejandro, Muñoz, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657540/
https://www.ncbi.nlm.nih.gov/pubmed/33175880
http://dx.doi.org/10.1371/journal.pone.0242184
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author Camprubí, Daniel
Almuedo-Riera, Alex
Martí-Soler, Helena
Soriano, Alex
Hurtado, Juan Carlos
Subirà, Carme
Grau-Pujol, Berta
Krolewiecki, Alejandro
Muñoz, Jose
author_facet Camprubí, Daniel
Almuedo-Riera, Alex
Martí-Soler, Helena
Soriano, Alex
Hurtado, Juan Carlos
Subirà, Carme
Grau-Pujol, Berta
Krolewiecki, Alejandro
Muñoz, Jose
author_sort Camprubí, Daniel
collection PubMed
description Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not receiving ivermectin. No differences were found between groups. We recommend the evaluation of high-doses of ivermectin in randomized trials against SARS-CoV-2.
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spelling pubmed-76575402020-11-18 Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients Camprubí, Daniel Almuedo-Riera, Alex Martí-Soler, Helena Soriano, Alex Hurtado, Juan Carlos Subirà, Carme Grau-Pujol, Berta Krolewiecki, Alejandro Muñoz, Jose PLoS One Research Article Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not receiving ivermectin. No differences were found between groups. We recommend the evaluation of high-doses of ivermectin in randomized trials against SARS-CoV-2. Public Library of Science 2020-11-11 /pmc/articles/PMC7657540/ /pubmed/33175880 http://dx.doi.org/10.1371/journal.pone.0242184 Text en © 2020 Camprubí et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Camprubí, Daniel
Almuedo-Riera, Alex
Martí-Soler, Helena
Soriano, Alex
Hurtado, Juan Carlos
Subirà, Carme
Grau-Pujol, Berta
Krolewiecki, Alejandro
Muñoz, Jose
Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
title Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
title_full Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
title_fullStr Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
title_full_unstemmed Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
title_short Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients
title_sort lack of efficacy of standard doses of ivermectin in severe covid-19 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657540/
https://www.ncbi.nlm.nih.gov/pubmed/33175880
http://dx.doi.org/10.1371/journal.pone.0242184
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