Genome-Wide CRISPR-Cas9 Screen Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection

Double-stranded RNA (dsRNA) is the hallmark of many viral infections. dsRNA is produced either by RNA viruses during replication or by DNA viruses upon convergent transcription. Synthetic dsRNA is also able to mimic viral-induced activation of innate immune response and cell death. In this study, we...

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Detalles Bibliográficos
Autores principales: Petitjean, Olivier, Girardi, Erika, Ngondo, Richard Patryk, Lupashin, Vladimir, Pfeffer, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657590/
https://www.ncbi.nlm.nih.gov/pubmed/33177215
http://dx.doi.org/10.1128/mSphere.00914-20

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