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Asthma in COVID-19 patients: An extra chain fitting around the neck?

INTRODUCTION: The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. METHODS...

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Autores principales: Hussein, Mohammad H., Toraih, Eman A., Attia, Abdallah S., Burley, Nicholas, Zhang, Allen D., Roos, Jackson, Houghton, August, Aniemeka, Nedum, Omar, Mahmoud, Aboueisha, Mohamed, Shama, Mohamed A., Duchesne, Juan, Kandil, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657611/
https://www.ncbi.nlm.nih.gov/pubmed/33217538
http://dx.doi.org/10.1016/j.rmed.2020.106205
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author Hussein, Mohammad H.
Toraih, Eman A.
Attia, Abdallah S.
Burley, Nicholas
Zhang, Allen D.
Roos, Jackson
Houghton, August
Aniemeka, Nedum
Omar, Mahmoud
Aboueisha, Mohamed
Shama, Mohamed A.
Duchesne, Juan
Kandil, Emad
author_facet Hussein, Mohammad H.
Toraih, Eman A.
Attia, Abdallah S.
Burley, Nicholas
Zhang, Allen D.
Roos, Jackson
Houghton, August
Aniemeka, Nedum
Omar, Mahmoud
Aboueisha, Mohamed
Shama, Mohamed A.
Duchesne, Juan
Kandil, Emad
author_sort Hussein, Mohammad H.
collection PubMed
description INTRODUCTION: The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. METHODS: We conducted a multi-center retrospective study of positively confirmed COVID-19 patients. The primary outcome of interest was in-hospital mortality. Secondary outcomes were the Intensive Care Unit (ICU) admission, intubation, mechanical ventilation, and length of hospital stay. RESULTS: A total of 502 COVID-19 adult patients (72 asthma and 430 non-asthma cohorts) with mean age of 60.7 years were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%. Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR = 1.81, 95%CI = 0.98–3.09, p = 0.06), endotracheal intubation (OR = 1.77, 95%CI = 0.99–3.04, p = 0.06) or complications (OR = 1.37, 95%CI = 0.82–2.31, p = 0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR = 1.48, 95%CI = 0.82–2.66, p = 0.20) or with ICU stay (OR = 0.76, 95%CI = 0.28–2.02, p = 0.58). Kaplan-Meier curve showed no significant difference in the overall survival of the two groups (p = 0.65). CONCLUSION: Despite the increased prevalence of hospitalization in elder asthmatic COVID-19 patients, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes.
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spelling pubmed-76576112020-11-12 Asthma in COVID-19 patients: An extra chain fitting around the neck? Hussein, Mohammad H. Toraih, Eman A. Attia, Abdallah S. Burley, Nicholas Zhang, Allen D. Roos, Jackson Houghton, August Aniemeka, Nedum Omar, Mahmoud Aboueisha, Mohamed Shama, Mohamed A. Duchesne, Juan Kandil, Emad Respir Med Article INTRODUCTION: The novel coronavirus disease 2019 (COVID-19) has rapidly spread across the globe. Pre-existing comorbidities have been found to have a dramatic effect on the disease course. We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. METHODS: We conducted a multi-center retrospective study of positively confirmed COVID-19 patients. The primary outcome of interest was in-hospital mortality. Secondary outcomes were the Intensive Care Unit (ICU) admission, intubation, mechanical ventilation, and length of hospital stay. RESULTS: A total of 502 COVID-19 adult patients (72 asthma and 430 non-asthma cohorts) with mean age of 60.7 years were included in the study. The frequency of asthma in hospitalized cohorts was 14.3%. Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). After adjustment, multivariable analysis showed that asthmatic patients were not associated with higher risk of ICU admission (OR = 1.81, 95%CI = 0.98–3.09, p = 0.06), endotracheal intubation (OR = 1.77, 95%CI = 0.99–3.04, p = 0.06) or complications (OR = 1.37, 95%CI = 0.82–2.31, p = 0.23). Asthmatic patients were not associated with higher odds of prolonged hospital length of stay (OR = 1.48, 95%CI = 0.82–2.66, p = 0.20) or with ICU stay (OR = 0.76, 95%CI = 0.28–2.02, p = 0.58). Kaplan-Meier curve showed no significant difference in the overall survival of the two groups (p = 0.65). CONCLUSION: Despite the increased prevalence of hospitalization in elder asthmatic COVID-19 patients, after adjustment for other variables, it was neither associated with increased severity nor worse outcomes. Elsevier Ltd. 2020-12 2020-11-11 /pmc/articles/PMC7657611/ /pubmed/33217538 http://dx.doi.org/10.1016/j.rmed.2020.106205 Text en © 2020 Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hussein, Mohammad H.
Toraih, Eman A.
Attia, Abdallah S.
Burley, Nicholas
Zhang, Allen D.
Roos, Jackson
Houghton, August
Aniemeka, Nedum
Omar, Mahmoud
Aboueisha, Mohamed
Shama, Mohamed A.
Duchesne, Juan
Kandil, Emad
Asthma in COVID-19 patients: An extra chain fitting around the neck?
title Asthma in COVID-19 patients: An extra chain fitting around the neck?
title_full Asthma in COVID-19 patients: An extra chain fitting around the neck?
title_fullStr Asthma in COVID-19 patients: An extra chain fitting around the neck?
title_full_unstemmed Asthma in COVID-19 patients: An extra chain fitting around the neck?
title_short Asthma in COVID-19 patients: An extra chain fitting around the neck?
title_sort asthma in covid-19 patients: an extra chain fitting around the neck?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657611/
https://www.ncbi.nlm.nih.gov/pubmed/33217538
http://dx.doi.org/10.1016/j.rmed.2020.106205
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