Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade

TGFβ is a pleiotropic cytokine that may have both tumor inhibiting and tumor promoting properties, depending on tissue and cellular context. Emerging data support a role for TGFβ in suppression of antitumor immunity. Here we show that SAR439459, a pan-TGFβ neutralizing antibody, inhibits all active...

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Detalles Bibliográficos
Autores principales: Greco, Rita, Qu, Hongjing, Qu, Hui, Theilhaber, Joachim, Shapiro, Gary, Gregory, Richard, Winter, Christopher, Malkova, Natalia, Sun, Frank, Jaworski, Julie, Best, Annie, Pao, Lily, Hebert, Andrew, Levit, Mikhail, Protopopov, Alexei, Pollard, Jack, Bahjat, Keith, Wiederschain, Dmitri, Sharma, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657645/
https://www.ncbi.nlm.nih.gov/pubmed/33224628
http://dx.doi.org/10.1080/2162402X.2020.1811605

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