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The impact of within-vector parasite development on the extrinsic incubation period
Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading to nearly half a million deaths each year. The malaria parasite requires a vertebrate host, such as a human, and a vector host, the Anopheles mosquito, to complete its full life cycle. Here, we focus on the p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657899/ https://www.ncbi.nlm.nih.gov/pubmed/33204441 http://dx.doi.org/10.1098/rsos.192173 |
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author | Childs, Lauren M. Prosper, Olivia F. |
author_facet | Childs, Lauren M. Prosper, Olivia F. |
author_sort | Childs, Lauren M. |
collection | PubMed |
description | Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading to nearly half a million deaths each year. The malaria parasite requires a vertebrate host, such as a human, and a vector host, the Anopheles mosquito, to complete its full life cycle. Here, we focus on the parasite dynamics within the vector to examine the first appearance of sporozoites in the salivary glands, which indicates a first time of infectiousness of mosquitoes. The timing of this period of pathogen development in the mosquito until transmissibility, known as the extrinsic incubation period, remains poorly understood. We develop compartmental models of within-mosquito parasite dynamics fitted with experimental data on oocyst and sporozoite counts. We find that only a fraction of oocysts burst to release sporozoites and bursting must be delayed either via a time-dependent function or a gamma-distributed set of compartments. We use Bayesian inference to estimate distributions of parameters and determine that bursting rate is a key epidemiological parameter. A better understanding of the factors impacting the extrinsic incubation period will aid in the development of interventions to slow or stop the spread of malaria. |
format | Online Article Text |
id | pubmed-7657899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-76578992020-11-16 The impact of within-vector parasite development on the extrinsic incubation period Childs, Lauren M. Prosper, Olivia F. R Soc Open Sci Mathematics Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading to nearly half a million deaths each year. The malaria parasite requires a vertebrate host, such as a human, and a vector host, the Anopheles mosquito, to complete its full life cycle. Here, we focus on the parasite dynamics within the vector to examine the first appearance of sporozoites in the salivary glands, which indicates a first time of infectiousness of mosquitoes. The timing of this period of pathogen development in the mosquito until transmissibility, known as the extrinsic incubation period, remains poorly understood. We develop compartmental models of within-mosquito parasite dynamics fitted with experimental data on oocyst and sporozoite counts. We find that only a fraction of oocysts burst to release sporozoites and bursting must be delayed either via a time-dependent function or a gamma-distributed set of compartments. We use Bayesian inference to estimate distributions of parameters and determine that bursting rate is a key epidemiological parameter. A better understanding of the factors impacting the extrinsic incubation period will aid in the development of interventions to slow or stop the spread of malaria. The Royal Society 2020-10-07 /pmc/articles/PMC7657899/ /pubmed/33204441 http://dx.doi.org/10.1098/rsos.192173 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Mathematics Childs, Lauren M. Prosper, Olivia F. The impact of within-vector parasite development on the extrinsic incubation period |
title | The impact of within-vector parasite development on the extrinsic incubation period |
title_full | The impact of within-vector parasite development on the extrinsic incubation period |
title_fullStr | The impact of within-vector parasite development on the extrinsic incubation period |
title_full_unstemmed | The impact of within-vector parasite development on the extrinsic incubation period |
title_short | The impact of within-vector parasite development on the extrinsic incubation period |
title_sort | impact of within-vector parasite development on the extrinsic incubation period |
topic | Mathematics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657899/ https://www.ncbi.nlm.nih.gov/pubmed/33204441 http://dx.doi.org/10.1098/rsos.192173 |
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