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Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells

Transcriptional regulation of the HOXA genes is thought to involve CTCF-mediated chromatin loops and the opposing actions of the COMPASS and Polycomb epigenetic complexes. We investigated the role of these mechanisms at the HOXA cluster in AML cells with the common NPM1c mutation, which express both...

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Detalles Bibliográficos
Autores principales:	Ghasemi, Reza, Struthers, Heidi, Wilson, Elisabeth R., Spencer, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657955/ https://www.ncbi.nlm.nih.gov/pubmed/32398790 http://dx.doi.org/10.1038/s41375-020-0856-3

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