Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

Substantial genetic liability is shared across psychiatric disorders but less is known about risk variants that are specific to a given disorder. We used multi-trait conditional and joint analysis (mtCOJO) to adjust GWAS summary statistics of one disorder for the effects of genetically correlated tr...

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Detalles Bibliográficos
Autores principales: Byrne, Enda M, Zhu, Zhihong, Qi, Ting, Skene, Nathan G, Bryois, Julien, Pardinas, Antonio F, Stahl, Eli, Smoller, Jordan W, Rietschel, Marcella, Owen, Michael J, Walters, James T.R., O’Donovan, Michael C, McGrath, John G, Hjerling-Leffler, Jens, Sullivan, Patrick F, Goddard, Michael E, Visscher, Peter M, Yang, Jian, Wray, Naomi R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657979/
https://www.ncbi.nlm.nih.gov/pubmed/32398722
http://dx.doi.org/10.1038/s41380-020-0705-9

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