Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation

Alcohol use disorder (AUD) is a chronic debilitating disorder with limited treatment options and poorly defined pathophysiology. There are substantial genetic and epigenetic components; however, the underlying mechanisms contributing to AUD remain largely unknown. We conducted the largest DNA methyl...

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Detalles Bibliográficos
Autores principales: Lohoff, Falk W., Roy, Arunima, Jung, Jeesun, Longley, Martha, Rosoff, Daniel B., Luo, Audrey, O’Connell, Emma, Sorcher, Jill L., Sun, Hui, Schwandt, Melanie, Hodgkinson, Colin A., Goldman, David, Momenan, Reza, McIntosh, Andrew M., Adams, Mark J., Walker, Rosie M., Evans, Kathryn L., Porteous, David, Smith, Alicia K., Lee, Jisoo, Muench, Christine, Charlet, Katrin, Clarke, Toni-Kim, Kaminsky, Zachary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658001/
https://www.ncbi.nlm.nih.gov/pubmed/32398718
http://dx.doi.org/10.1038/s41380-020-0734-4

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