Metabolism and Pharmacokinetic Drug–Drug Interaction Profile of Vericiguat, A Soluble Guanylate Cyclase Stimulator: Results From Preclinical and Phase I Healthy Volunteer Studies

BACKGROUND: Vericiguat is a stimulator of soluble guanylate cyclase currently under investigation as a first-in-class therapy for worsening chronic heart failure (NCT02861534). Patients with heart failure often require polypharmacy because of comorbidities. Hence, understanding the clearance mechani...

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Detalles Bibliográficos
Autores principales: Boettcher, Michael, Gerisch, Michael, Lobmeyer, Maximilian, Besche, Nina, Thomas, Dirk, Gerrits, Mireille, Lemmen, Julia, Mueck, Wolfgang, Radtke, Martin, Becker, Corina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658073/
https://www.ncbi.nlm.nih.gov/pubmed/32458378
http://dx.doi.org/10.1007/s40262-020-00895-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658073/
https://www.ncbi.nlm.nih.gov/pubmed/32458378
http://dx.doi.org/10.1007/s40262-020-00895-x

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